ijms-logo

Journal Browser

Journal Browser

Antioxidant, Anti-tumour, and Anticoagulant Activities of Bioactive Compounds from Natural Products

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".

Deadline for manuscript submissions: closed (31 December 2023) | Viewed by 1736

Special Issue Editor


E-Mail Website
Guest Editor

Special Issue Information

Dear Colleagues,

Nature provides an incredible range of chemical compounds with medicinal benefits. Bioactive compounds originate from natural sources, including plants, microbes, and animals. According to the available studies, bioactive components can enhance pharmacological efficacy at lower doses, hence decreasing dosage toxicity. Bioactive compounds include alkaloids, isoprenoids, phenylpropanoids, xanthones, peptides, polysaccharides, glucosinolates, curcumin, resveratrol, anthraquinones, bilirubin, betaxanthin, betacyanin, lycopene, phytosterols, and β-sitosterol, etc. have shown outstanding pharmacological effects in various in vitro and in vivo paradigms.

Bioactive compounds can inhibit cell growth and migration, inducing cell cycle arrest and apoptosis and restoring the sensitivity of tumor cells to conventional anticancer drugs. Thrombosis leads to severe complications if clots get dislodged and move to crucial parts of the circulatory system, and it remains a significant reason for mortality worldwide. Anticoagulants inhibit various factors of coagulation pathways and are one of the two main classes of antithrombotic therapy. The aim of this Special Issue is to collect original research articles, as well as review articles, addressing recent advances in the applications of bioactive compounds in antioxidant, anti-tumor, and anticoagulant activities from natural products. In addition, nanotechnology can enhance natural substances' delivery with demonstrated medicinal potential.

Dr. Muthu Thiruvengadam
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bioactive compounds
  • natural products
  • antioxidants
  • blood coagulation
  • anticoagulants
  • anticancer
  • nanomedicines
  • nanotechnology
  • medicinal plants
  • metabolomics

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

19 pages, 7639 KiB  
Article
Macrofungal Mediated Biosynthesis of Silver Nanoparticles and Evaluation of Its Antibacterial and Wound-Healing Efficacy
by Gayathri Vijayakumar, Hyung Joo Kim, Jeong Wook Jo and Senthil Kumaran Rangarajulu
Int. J. Mol. Sci. 2024, 25(2), 861; https://doi.org/10.3390/ijms25020861 - 10 Jan 2024
Cited by 1 | Viewed by 1321
Abstract
Recently, the utilization of biological agents in the green synthesis of nanoparticles has been given interest. In this study, silver nanoparticles were synthesized from an aqueous extract of macrofungus (mushroom), namely Phellinus adamantinus, in a dark room using 20 µL of silver nitrate. [...] Read more.
Recently, the utilization of biological agents in the green synthesis of nanoparticles has been given interest. In this study, silver nanoparticles were synthesized from an aqueous extract of macrofungus (mushroom), namely Phellinus adamantinus, in a dark room using 20 µL of silver nitrate. Biosynthesized silver nanoparticles were confirmed by analyzing them using a UV-Vis (ultraviolet-visible) spectrophotometer. The synthesized silver nanoparticles were optimized at different pH and temperatures with various dosages of AgNO3 (silver nitrate) and fungal extracts. The synthesized AgNPs (silver nanoparticles) were characterized using TEM (transmission electron microscopy) and EDX (energy-dispersive X-ray) analyses, which confirmed the presence of silver nanoparticles. The size of the nanosilver particles was found to be 50 nm with higher stability. The mycosynthesized AgNPs showed effective antibacterial activity against strains of Gram-positive (Staphylococcus aureus and Bacillus subtilis) and Gram-negative (E. coli and Pseudomonas aeruginosa) bacteria. The minimum inhibitory concentration (MIC) was found to be 3.125 μg/mL by MIC assay. The MTT assay (3-[4,5-dimethylthiazol-2-yl] 2,5-diphenyl-2H-tetrazolium bromide) was performed to study cytotoxicity, and reduced cell viability was recorded at 100 μg/mL. Silver-Polygalacturonic acid-Polyvinyl alcohol ((Ag-PGA)-PVA) nanofiber was prepared using the electrospinning method. The in vitro wound scratch assay was demonstrated to study the wound-healing efficacy of the prepared nanofiber. The wound-healing efficacy of the AgNP-incorporated nanofiber was found to be 20% after 24 h. This study will lay a platform to establish a unique route to the development of a novel nanobiomaterial and its application in antibacterial and wound-healing therapy. Full article
Show Figures

Figure 1

Back to TopTop