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Organic Compounds: Structure, Function and Drug Design

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Macromolecules".

Deadline for manuscript submissions: 29 September 2024 | Viewed by 379

Special Issue Editor


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Guest Editor
Dipartimento di Scienze Chimiche, Biologiche, Farmaceutiche ed Ambientali, University of Messina, Viale Annunziata, 98168 Messina, Italy
Interests: proteasome inhibitors; multiple myeloma therapy; cysteine protease inhibitors; tropical diseases

Special Issue Information

Dear Colleagues,

The development of new drugs is needed to treat different types of diseases related to parasites, virus, bacteria, or fungi and to cure human diseases such as cancer or autoimmune/inflammatory pathologies. In this context, medicinal chemistry can lead to the identification of novel compounds that show pharmacological properties. These novel chemical entities can be chemically synthesized or isolated and purified from natural sources, or they can sometimes be used in combination with a synthetic drug and a nutraceutical.

In this Special Issue, we welcome studies that report on the synthesis/isolation/functionalization/characterization and biological activities of synthetic compounds or of organic compounds obtained from natural sources endowed with biological activity to serve as drug candidates for diseases that impair public health.

Dr. Roberta Ettari
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • chemical entities
  • nutraceuticals
  • parasite
  • virus
  • bacteria
  • cancer
  • autoimmune diseases
  • inflammatory diseases

Published Papers (1 paper)

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Review

22 pages, 4072 KiB  
Review
The Inhibition of NS2B/NS3 Protease: A New Therapeutic Opportunity to Treat Dengue and Zika Virus Infection
by Josè Starvaggi, Santo Previti, Maria Zappalà and Roberta Ettari
Int. J. Mol. Sci. 2024, 25(8), 4376; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms25084376 - 16 Apr 2024
Viewed by 302
Abstract
In the global pandemic scenario, dengue and zika viruses (DENV and ZIKV, respectively), both mosquito-borne members of the flaviviridae family, represent a serious health problem, and considering the absence of specific antiviral drugs and available vaccines, there is a dire need to identify [...] Read more.
In the global pandemic scenario, dengue and zika viruses (DENV and ZIKV, respectively), both mosquito-borne members of the flaviviridae family, represent a serious health problem, and considering the absence of specific antiviral drugs and available vaccines, there is a dire need to identify new targets to treat these types of viral infections. Within this drug discovery process, the protease NS2B/NS3 is considered the primary target for the development of novel anti-flavivirus drugs. The NS2B/NS3 is a serine protease that has a dual function both in the viral replication process and in the elusion of the innate immunity. To date, two main classes of NS2B/NS3 of DENV and ZIKV protease inhibitors have been discovered: those that bind to the orthosteric site and those that act at the allosteric site. Therefore, this perspective article aims to discuss the main features of the use of the most potent NS2B/NS3 inhibitors and their impact at the social level. Full article
(This article belongs to the Special Issue Organic Compounds: Structure, Function and Drug Design)
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