Local Control of Thyroid Hormone Action 2.0

Dear Colleagues,

This Special Issue is the continuation of our 2022 Special Issue “Local Control of Thyroid Hormone Action”.

Thyroid hormones (TH) regulate many cellular processes, including proliferation, differentiation, and mitochondrial activity. Thus, proper TH signaling is critical for the homeostasis of almost all tissues and essential for normal brain development. According to the classical view, cell-specific TH action is largely determined by circulating TH concentrations that, in turn, are predominantly regulated by the activity of the hypothalamus–pituitary–thyroid axis. The discovery of different (1) TH transporters facilitating TH access to target cells, (2) deiodinases activating or inactivating TH intracellularly, as well as (3) distinct TH receptors and modes of intracellular receptor signaling has challenged this view and has shifted the focus from systemic TH levels toward the molecular components controlling local TH action. A broader understanding of TH transporters, deiodinase, receptors and their (patho-)physiological regulation will shed light on the molecular mechanisms underlying rare as well as common diseases with distinct changes in local TH homeostasis. Such knowledge will pave the ground for the development of pharmacological tools that may ultimately result in novel therapeutic approaches by modulating TH signaling in a cell-specific manner.

This Special Issue of the International Journal of Molecular Sciences focuses on TH transporters, deiodinases, and TH receptors and welcomes both original research articles and reviews that address molecular mechanisms underlying local control of TH signaling in health and disease.

Prof. Dr. Heike Heuer
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• TH receptors
• deiodinases
• TH transporters
• canonical/noncanonical signaling
• TH metabolism
• pathophysiology
• animal model
• hiPSC

• Local Control of Thyroid Hormone Action in International Journal of Molecular Sciences (12 articles)