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Special Issue "Therapeutic Approaches for Aging-Related Lung Disease"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: closed (30 November 2020).

Special Issue Editors

Dr. Stefanie Krick
E-Mail Website
Guest Editor
Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, The University of Alabama at Birmingham, Birmingham, AL 35294, USA
Interests: inflammatory lung diseases; aging; fibroblast growth factor signaling; klotho; cystic fibrosis; chronic obstructive pulmonary disease; pulmonary vascular remodeling; fibroblast growth factor 23
Special Issues, Collections and Topics in MDPI journals
Dr. Jarrod Barnes
E-Mail Website
Guest Editor
Allergy and Critical Care Medicine, University of Alabama at Birmingham, Birmingham, AL, USA
Interests: glycobiology; pulmonary vascular disease; fibroblast growth factor signalling; vascular remodelling; vascular smooth muscle cells; and pulmonary hypertension; aging; pulmonary fibrosis
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Aging is a major risk factor for chronic diseases of the lung, including chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis (IPF). Different hallmarks of the aging lung have been identified, including telomere attrition, epigenetics, proteostasis, deregulated nutrient sensing, metabolism, cellular senescence, and adaptation to stress. However, therapeutic approaches to target these hallmarks are still lacking. 

This Special Issue of the International Journal of Molecular Sciences will focus on “Therapeutic Approaches for Aging-Related Lung Disease.” While current data suggest the importance of accelerated aging in chronic lung disease, there is no cure, and therapy options are limited. Therefore, this Special Issue will solicit new research manuscripts (basic, clinical or translational) related to new insights into current therapeutic strategies and novel targets/mediators to treat aging-related lung disease.

Dr. Stefanie Krick
Dr. Jarrod Barnes
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • aging
  • pulmonary fibrosis
  • cell senescence
  • inflammation
  • klotho
  • COPD
  • IPF
  • mitochondrial dysfunction
  • nutrient sensing

Published Papers (1 paper)

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Review

Review
Targeting Aging Pathways in Chronic Obstructive Pulmonary Disease
Int. J. Mol. Sci. 2020, 21(18), 6924; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21186924 - 21 Sep 2020
Cited by 4 | Viewed by 2549
Abstract
Chronic obstructive pulmonary disease (COPD) has become a global epidemic and is the third leading cause of death worldwide. COPD is characterized by chronic airway inflammation, loss of alveolar-capillary units, and progressive decline in lung function. Major risk factors for COPD are cigarette [...] Read more.
Chronic obstructive pulmonary disease (COPD) has become a global epidemic and is the third leading cause of death worldwide. COPD is characterized by chronic airway inflammation, loss of alveolar-capillary units, and progressive decline in lung function. Major risk factors for COPD are cigarette smoking and aging. COPD-associated pathomechanisms include multiple aging pathways such as telomere attrition, epigenetic alterations, altered nutrient sensing, mitochondrial dysfunction, cell senescence, stem cell exhaustion and chronic inflammation. In this review, we will highlight the current literature that focuses on the role of age and aging-associated signaling pathways as well as their impact on current treatment strategies in the pathogenesis of COPD. Furthermore, we will discuss established and experimental COPD treatments including senolytic and anti-aging therapies and their potential use as novel treatment strategies in COPD. Full article
(This article belongs to the Special Issue Therapeutic Approaches for Aging-Related Lung Disease)
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