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Topical Collection "Antifungal Compounds"

A topical collection in International Journal of Molecular Sciences (ISSN 1422-0067). This collection belongs to the section "Biochemistry".


Prof. Dr. Giorgio Pelosi
E-Mail Website
Collection Editor
Department of Chemistry, Life Sciences and Environmental Sustainability, University of Parma, Parma, Italy
Interests: metal complexes; biological properties; sulfur containing ligands; thiosemicarbazones; anticancer compounds; antiviral compounds; metal-based antibiotics; antimycotic compounds; antioxidants; apoptosis; X-ray diffraction; inorganic synthesis; topoisomerase IIA; phototherapy; nanoparticles

Topical Collection Information

Dear Colleagues,

A fungicide is any agent that can prevent, moderate, repel or even kill fungi. Being widely applied as a treatment against both human and plant pathogens as well as a preservative additive for food commodities or for the conservation of porous building materials in monuments, fungicides have undoubtedly become a feature that the environment has to cope with. The mode of action of antifungals is closely related to specific metabolic pathways; however, despite certain similarities between fungi and animals, such mechanisms are frequently difficult to elucidate. Additionally, due to the increase in occurrences of resistance, the beneficial role of known fungicides is rapidly declining, which poses a serious threat to human health and agriculture and creates a vulnerability to fungi in both plants and animals. Today, since new strategies are required to face new problems, it is necessary more than ever to promote investigations focused on the molecular mechanisms surrounding the biological activity of fungicide/fungistatic compounds in order to provide crucial insights on fungicides that could potentially be strategic for their implementation.

In this Topical Collection, the most recent scientific advances on the molecular mechanisms behind fungicides’ biological activity, use, physical state, pathophysiological effects and sources will be presented. Research manuscripts and review articles focused on the cellular/molecular mechanisms of fungicide-promoted toxicity in target and non-target organisms, biodegradation, biotransformation and bioaccumulation, innovative formulation technologies, lead projects aimed at the development of new generation antifungal bioactives or overcoming fungicide resistance will be considered.

Prof. Dr. Giorgio Pelosi
Collection Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the collection website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Antifungal compounds
  • Fungicides
  • Bioactives
  • Fungal pathogen drug resistance
  • Fungal growth inhibitors
  • Fungi containment
  • Antimicrobial molecules
  • Fungal toxic metabolites
  • Aflatoxin
  • Sterigmatocystin

Published Papers (1 paper)


Open AccessArticle
The AFLATOX® Project: Approaching the Development of New Generation, Natural-Based Compounds for the Containment of the Mycotoxigenic Phytopathogen Aspergillus flavus and Aflatoxin Contamination
Int. J. Mol. Sci. 2021, 22(9), 4520; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22094520 - 26 Apr 2021
Viewed by 577
The control of the fungal contamination on crops is considered a priority by the sanitary authorities of an increasing number of countries, and this is also due to the fact that the geographic areas interested in mycotoxin outbreaks are widening. Among the different [...] Read more.
The control of the fungal contamination on crops is considered a priority by the sanitary authorities of an increasing number of countries, and this is also due to the fact that the geographic areas interested in mycotoxin outbreaks are widening. Among the different pre- and post-harvest strategies that may be applied to prevent fungal and/or aflatoxin contamination, fungicides still play a prominent role; however, despite of countless efforts, to date the problem of food and feed contamination remains unsolved, since the essential factors that affect aflatoxins production are various and hardly to handle as a whole. In this scenario, the exploitation of bioactive natural sources to obtain new agents presenting novel mechanisms of action may represent a successful strategy to minimize, at the same time, aflatoxin contamination and the use of toxic pesticides. The Aflatox® Project was aimed at the development of new-generation inhibitors of aflatoxigenic Aspergillus spp. proliferation and toxin production, through the modification of naturally occurring molecules: a panel of 177 compounds, belonging to the thiosemicarbazones class, have been synthesized and screened for their antifungal and anti-aflatoxigenic potential. The most effective compounds, selected as the best candidates as aflatoxin containment agents, were also evaluated in terms of cytotoxicity, genotoxicity and epi-genotoxicity to exclude potential harmful effect on the human health, the plants on which fungi grow and the whole ecosystem. Full article
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