Special Issue "Advances in Aptamers for Cancer Targeting"
Deadline for manuscript submissions: 28 February 2022.
A Special Issue on the hot topic of “Advances in Aptamers for Cancer Targeting” is being prepared for the IJMS. This Special Issue is aimed at summarizing the most recent applications of aptamers for the classification/characterization, diagnosis, and/or treatment of the major cancer types.
Given their ability to bind with high-affinity and high-specificity cancer biomarkers, nucleic acid aptamers represent promising candidates as tools for new target discovery as well as for imaging probes, capture agents, and anticancer drug development. Aptamers exhibit similar functionality to antibodies but show several advantages over them, including easy and fast production, low costs, low immunogenicity, and high versatility. Due to their chemical nature, aptamers are suitable for receiving various chemical modifications to improve their features for clinical development. In addition, aptamers against cell surface receptors upon binding to their target may undergo receptor-mediated intracellular uptake; thus, they represent effective carriers for the targeted delivery of secondary reagents (e.g., fluorophores, magnetic nanoparticles, small interfering RNAs, microRNAs, antimiRs, small drugs, and toxins) for both diagnostic and therapeutic purposes.
Original manuscripts and reviews dealing with the selection, characterization, development, and/or application of aptamers for the selective targeting of tumors are welcomed from experts of the topic.
Dr. Silvia Catuogno
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
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- biomarker discovery
- targeted therapy
- targeted delivery