Topical Collection "Targeted Protection of Bioactive Natural Products to Mitochondria Functions"
Interests: natural products; inflammation; signal transduction; transcription factors; gene expression; antitumor therapy
The focus of this issue is to investigate the mechanism(s) of action of natural molecules targeting mitochondria and being effective in preventing or counteracting human diseases.
Mitochondria functionalities are very important to maintain energy homeostasis, cellular metabolism, and to control cell stress responses. Mitochondria are the main intracellular source of reactive oxygen species and are very dynamic organelles because they respond to insults by fission or fusion, induce autophagy or apoptosis, and finally control cell life or death. Therefore, mitochondria fulfill great relevance in biomedicine. Indeed, their activity dysregulation results in pathological processes like inflammation, aging, carcinogenesis, and neurodegeneration.
In this scenario, many natural compounds are active in affecting specific mitochondrial enzymes, and in modulating the signaling from or to mitochondria. Thus, the mitochondrion represents an emerging target for molecules deriving from natural sources that can open in turn new therapeutic perspectives for the prevention and cure of metabolic disorders and other human diseases.
We welcome here submissions of studies on the effects of natural compounds on mitochondria and on their nutritional applications using molecular biology, as well as biochemical, cellular, and immunological methods.
Importantly, the exact active ingredient of a vegetable extract must be reported in the submitted research manuscript, since papers describing effects of mixed extraction from plants are not accepted.
Prof. Dr. Marta Menegazzi
Manuscript Submission Information
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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
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- natural products
- mitochondrial function
- mitochondrial dynamic
- energy homeostasis
- aging, apoptosis