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Special Issue "Calcium Channel Regulation in Cancer: Unravelling the Molecular Mechanisms beneath the Membrane"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: 1 February 2022.

Special Issue Editor

Assoc. Prof. Dimitra Gkika
E-Mail Website
Guest Editor
CANcer Heterogeneity, Plasticity and Resistance to THERapies Lab, Faculty of Sciences and Technologies, University of Lille, 59000 Lille, France
Interests: ion channel; TRP channel; calcium homeostasis; cancer; angiogenesis; small GTPases; androgen receptor; steroid fast non genomic actions; expression profile; cell migration; cell adhesion

Special Issue Information

Dear Colleagues,

Over the last decades, an increasing number of calcium channels located at the cell surface or inner membranes, including voltage-dependent calcium channels (VDCC), transient receptor potential (TRP), store-operated calcium (SOC) channels, the inositol 1,4,5-trisphosphate receptor (IP3R), and mitochondrial calcium uniporter (MCU), have been suggested as clinical markers and/or therapeutical targets for cancer. In this perspective, major advances have contributed to a deeper understanding of the regulatory mechanisms controlling the channel activity, as well as its consequences in tumour initiation, growth, and metastasis.

I therefore would like to invite you to participate in this Special Issue, "Calcium Channel Regulation in Cancer: Unravelling the Molecular Mechanisms beneath the Membrane", by presenting your most recent research or ideas about intracellular factors such as channel associated factors, kinases, partner proteins, small GTPases, calcium binding proteins, signalling molecules affecting channel functioning, and the consequential major aspects of carcinogenesis.

Assoc. Prof. Dimitra Gkika
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • ion channel
  • calcium signalling
  • partner protein
  • protein–protein interaction
  • TRP channel
  • channel subunit
  • TRP
  • ORAI
  • CaV
  • IP3R
  • MCU
  • cancer
  • tumour initiation
  • tumour growth
  • metastasis

Published Papers

This special issue is now open for submission.
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