Special Issue "Activity, Function and Druggability of Cancer-Related Enzymes"
Deadline for manuscript submissions: 30 July 2021.
Interests: medicinal chemistry; drug design; computational chemistry; carbonic anhydrases; enzymatic evaluation
Interests: drug design; medicinal chemistry; pharmaceutical organic synthesis
Interests: medicinal chemistry; drug design; enzyme inhibition; multicomponent reactions
Cancer remains a major cause of mortality and morbidity worldwide despite numerous studies have been and are being conducted to improve tumor prevention, early diagnosis and treatment.
Traditionally, several enzymes regulating cell division or involved in DNA replication have been considered valuable anticancer drug targets. Furthermore, alterations of the energy metabolism are among the main hallmarks of cancers making targeting glycolytic pathway enzymes an effective means for treating the disease. Finally, several enzymes have been used as biomarkers for cancer identification and validation being under- or over-expressed in various tumors. As a result, many such enzymes have been also validated as targets for therapeutic intervention. Accordingly, several main classes of cancer-related enzymes can be allocated, such as:
- Glycolytic enzymes (e.g. lactate dehydrogenase A, glucose-6-phosphate dehydrogenase)
- Oncogenic signal transduction enzymes (e.g. kinases, phosphatases)
- DNA-related enzymes (e.g. DNA polymerase, topoisomerase, telomerase)
- Extracellular enzymes (e.g. carbonic anhydrases, matrix metalloproteases, ecto-5′-nucleotidase)
It is noteworthy that nonglycolytic enzymes such as carbonic anhydrases (CAs) IX and XII play a major role in the metabolic switch of tumor cells. Indeed, the resulting intracellular acidosis, incompatible with basic cellular functions, induces tumor cells to activate complex molecular mechanisms, actively involving CA IX and XII among other proteins, that restore the intracellular pH and acidify the extracellular pH to promote cancer survival and proliferation.
Targeting enzymatic variations of tumor cells shown to be associated with cancer progression offers a huge potential and remains a largely unexplored topic for developing new anti-cancer therapies. This Special Issue is dedicated to all important advances in the field of cancer-related enzymes as biomarkers and therapeutic targets for the diagnosis and treatment of tumors.
Original papers, reviews articles, and perspectives from experts in the field are welcome.
Dr. Alessio Nocentini
Dr. Wagdy M. Eldehna
Dr. Stanislav Kalinin
Manuscript Submission Information
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- Metabolic switch
- Cancer epigenetics
- Signal transduction