Special Issue "Cannabinoid Signaling in Nervous System"
Deadline for manuscript submissions: closed (30 September 2017).
Interests: endocannabinoisd system; adolescence; psychiatric disorders; autism
The discovery in 1990 that the effects of delta-9 tetrahydrocannabinol (THC), the main psychoactive component present in Cannabis sativa, were mediated by its interaction with a specific receptor, represented the starting point for the characterization of what is now called the endocannabinoid system (ECS).
The initial picture showed that the ECS comprised two main receptors, CB1 and CB2, the endocannabinoids (the best known are anandamide and 2-arachidonoylglycerol) as well as the enzymes responsible for their synthesis and degradation. In the last few years, additional receptors and enzymes have been discovered, adding complexity to the system. In the meantime, growing evidence indicates that dysregulation of the ECS plays a key role in several pathologies of the nervous system, thus opening the way to the possibility of targeting ECS for therapeutic purposes.
Therefore, this Special Issue will provide an updated knowledge of both the physiology of the ECS signaling and its involvement in the neurobiology of several disorders of the nervous system.
Prof. Dr. Daniela Parolaro
Prof. Dr. Tiziana Rubino
Manuscript Submission Information
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- cannabinoid receptors
- CNS development
- autism spectrum disorder
- neurodegenerative diseases
- sex differences