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Special Issue "Carbonic Anhydrase and Biomarker Research 2021"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: 30 November 2021.

Special Issue Editor

Special Issue Information

Dear Colleagues,

Carbonic anhydrase is a widely distributed metalloenzyme catalysing the reversible hydration of CO2 to HCO3- and H+. It plays a fundamental role in a number of physiological processes, including gas exchange, pH homeostasis, electrolyte transport, metabolic reactions, bone resorption, and calcification. Recently, its involvement in several pathological conditions, as well as sensitivity to chemical pollutants, has advanced the research on carbonic anhydrase in the biomarker discovery field.

A biomarker is defined as a cellular, biochemical, or molecular alteration that is measurable in biological media as an indicator of normal biological process, pathogenic processes, or response to an exposure or intervention. Biomarkers are useful tools in a wide range of fields, including medicine, drug discovery, environmental health, and ecotoxicology.

In recent years, alteration in the expression of specific carbonic anhydrase isoforms has been proposed as diagnostic or prognostic biomarkers in the clinical field, mainly in cancer research.

Moreover, the sensitivity of specific carbonic anhydrase isoforms to environmental pollutants has given rise to new perspectives in the potential use of carbonic anhydrase as a pollution biomarker.

This Special Issue of IJMS is aimed to cover the more recent insights into the research of carbonic anhydrase as a promising biomarker in several areas of interest, from human health to environmental sciences, opening new perspectives for the translation of advances in basic sciences on this ancient enzyme into innovative applications.

Prof. Dr. Maria Giulia Lionetto
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • carbonic anhydrase
  • biomarker
  • pH regulation
  • cancer
  • tumor microenvironment
  • heavy metals
  • pollutant
  • biomonitoring

Published Papers

This special issue is now open for submission.
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