Special Issue "Drug Hypersensitivity"
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (30 April 2017).
Interests: drug hypersensitivity; T cell activation; p-i concept; drug binding to HLA or TCR; T cell activation; IgE reaction with drugs; pseudo-allergy; clinic of drug hypersensitivity
The old immunological dogma that small molecules do not interfere with the specific immune system was recently challenged by studying patients with drug hypersensitivity reactions: Drugs were found to be able to directly bind to immune receptors like HLA or TCR and thus lead to immune activations (pharmacological interaction with immune receptors, p-i concept). This finding was surprising as it opened a new area of basic immunology, namely how small molecules interact with the immune system; and it demonstrated once again that an in depth study of an acquired, human disease can also contribute to our understanding of basic scientific principles.
In this Special Issue of IJMS, a collection of papers will address the various mechanism of drug hypersensitivity: By linking molecular and clinical research of drug hypersensitivity, the role of small molecules in specific immunity in general may be better clarified. This should have an impact on incidence and severity and prediction of drug hypersensitivity reactions and may also help to understand other, environmental or man-made diseases.
Prof. Dr. Werner J. Pichler
Manuscript Submission Information
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- p-i concept
- basophil activation test
- T cell stimulation