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Special Issue "Endocrine Disruption and Human Diseases"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Toxicology".

Deadline for manuscript submissions: 31 January 2022.

Special Issue Editor

Dr. Yuet-Kin Leung
E-Mail Website
Guest Editor
Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
Interests: endocrine disruptors; hormonal cancer; nuclear receptors; epigenetics; gene regulation; stem cells

Special Issue Information

Dear Colleagues,

Hormone is one of the essential factors for supporting growth and differentiation in humans. Any disruption by hormone mimetics existing in our environment at specific critical developmental windows (including prenatal, lactational, pubertal and pregnancy windows) could lead to detrimental effects, especially in those hormone-dependent tissues/organs. Not only would this disturb the preset developmental programs but also would heighten the risk for carcinogenesis via epigenetics reprogramming. Several classes of environmental endocrine disruptors have been identified and investigated. These include perfluoroalkyl and polyfluoroalkyl substances (PFAS), bisphenols (BPA/BPS), polychlorinated biphenyls (PCBs), phthalates (DEHP/DEP), pesticides (DDT/DDE), brominated flame retardants (PBDEs) and dioxins (PCDDs). The latest research findings revealed that some of these chemicals exhibit non-classical toxicological profiles i.e. prominent effects at the low dose, non-monotonic dose responses as well as multi-generation effects.

This Special Issue will cover a selection of recent research topics and current review articles in the field of “Endocrine disruption and Cancer”. Experimental papers, up-to-date review articles, and commentaries are all welcome.

Dr. Yuet-Kin Leung
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • environmental estrogens
  • developmental origins of health and disease
  • windows of susceptibility
  • transgeneration
  • endocrine-disrupting chemicals (EDC)
  • exposure

Published Papers

This special issue is now open for submission.
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