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Special Issue "Proteinopathies in Frontotemporal Lobar Degeneration"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".

Deadline for manuscript submissions: 31 August 2021.

Special Issue Editor

Dr. Massimo Filippi
E-Mail Website
Guest Editor
Neurology Unit, Neurorehabilitation Unit, Neurophysiology Service, and Neuroimaging Research Unit, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Via Olgettina, 60, 20132 Milan, Italy
Interests: the definition of the mechanisms leading to progressive accumulation of irreversible physical disability and cognitive impairment in various neurological conditions

Special Issue Information

Dear Colleagues,

This Special Issue is dedicated to the study of the molecular underpinnings of clinical variants of the frontotemporal lobar degeneration (FTLD) spectrum and will publish a collection of original studies or review articles related to this topic. In contrast to the relative pathological homogeneity of other neurodegenerative diseases (e.g., Alzheimer’s disease or Parkinson’s disease), FTLD variants have been associated with a variety of underlying proteinopathies, including tau, TDP-43 and FUS. The influence of the genetic background, brain network architecture and neurochemical microstructural environment over such diverging pathways of neurodegeneration is an area of intense research and the topic of the present issue. The continued identification of pathogenically relevant genes, genotype–phenotype correlations and novel approaches that may provide accurate, early diagnostic biomarkers, even in the presymptomatic stages of FTLD disorders, will be addressed. Only translational studies in human subjects will be accepted, in order to highlight the potential development and implementation of therapeutic strategies in this heterogeneous group of diseases.

Dr. Massimo Filippi
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Frontotemporal lobar degeneration
  • Neuropathology
  • TDP-43
  • Tau
  • FUS
  • Proteinopathies
  • Neurodegeneration
  • Dementia
  • Biomarkers
  • Diagnostics and therapeutics
  • Genetics

Published Papers

This special issue is now open for submission.
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