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Special Issue "New Findings and Insights in Inflammation-Induced DNA Damage, Mutations and Cancer"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Genetics and Genomics".

Deadline for manuscript submissions: 31 May 2022.

Special Issue Editor

Dr. Jennifer Kay
Guest Editor
Silent Spring Institute, Newton, MA, USA
Interests: inflammation; DNA damage and repair; mutagenesis; mechanisms of carcinogenesis, adverse outcome pathways

Special Issue Information

Dear Colleagues,

We are seeking to gauge interest in submitting articles to a Special Issue curated by the International Journal of Molecular Sciences on “New Findings and Insights in Inflammation-Induced DNA Damage, Mutations and Cancer”.

Inflammation and mutagenesis are well-known hallmarks of cancer, and while the mechanisms linking inflammation or mutagenesis to cancer are frequently interrogated, the interrelationships between inflammation and mutagenesis and subsequent influences on cancer are less well studied. DNA damage is a key node in the network that connects inflammation and mutagenesis—inflammation both causes and is caused by DNA damage, and DNA damage is the dominant cause of mutagenesis (aside from spontaneous replication errors). Additionally, increases in cellular proliferation (a result of inflammation and a feature of carcinogenesis) sensitize cells to DNA damage-induced mutations. Environmental exposures and endogenous processes can increase inflammation, DNA damage, and/or proliferation, in turn provoking the progressive accumulation of mutations that leads to carcinogenesis. Interrogation of the cellular signaling mechanisms underlying inflammation, DNA damage, and proliferation will also provide insight into key events in the pathway, from inflammation and/or exposure to the adverse outcome of cancer. As such, integrated studies of inflammation, DNA damage, cellular proliferation, and mutagenesis are needed to elucidate the mechanisms of cancer development, to evaluate chemicals for carcinogenic potential, and to identify potential opportunities for intervention.

This Special Issue of the International Journal of Molecular Sciences is dedicated to recent advances in understanding the complex relationships between inflammation, DNA damage, and mutagenesis that govern cancer development.

Dr. Jennifer Kay
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  •  Inflammation
  • DNA damage
  • DNA repair
  • Mutagenesis
  • Carcinogenesis
  • Cell signaling
  • Oxidative stress
  • Integrated pathway analysis
  • Tumor microenvironment
  • DNA damage response
  • Cellular proliferation

Published Papers

This special issue is now open for submission, see below for planned papers.

Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Title: Pathological role of cell-free DNA in tumor and metastasis progression: perspectives of DNases application as antitumor and antimetastatic agents
Authors: Alekseeva L.A.; Mironova N.L.
Affiliation: Laboratory of Nucleic Acids Biochemistry, Institute of Chemical Biology and Fundamental Medicine SB RAS, Novosibirsk, Russia

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