Interplay between Transcription Factors and Genome Organization
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Genetics and Genomics".
Deadline for manuscript submissions: closed (31 December 2022) | Viewed by 3064
Special Issue Editor
Interests: eukaryotic RNA polymerases; retrotransposons; transcription factors; gene regulation; chromatin
Special Issue Information
Dear Colleagues,
Transcription factors (TFs) govern cell-type-specific gene expression programs by binding enhancer elements in a sequence-specific manner, thereby ultimately directing activation or repression of specific promoters. In so doing, TFs also exert a profound influence on the three-dimensional (3D) organization of nuclear chromatin, for example, by driving the formation of DNA loops that favor enhancer–promoter contacts. Such contacts occur within larger chromosomal loop structures, formed by the interaction of architectural proteins bound to each of the loop anchors. Compartments and topologically associating domains (TADs) in 3D genome architecture do in turn shape TF activity, so that the interdependency of TF activity and 3D genome organization is increasingly being recognized as a key factor of gene regulation in living cells. Adding to this complexity, general transcription factors (GTFs) which are expressed in virtually all cell types and are usually placed in the proximity of gene transcription start sites (TSS) have recently been shown to also occupy distal enhancer elements and to act as a new player in shaping the 3D genome and the transcription programs which define different cell identities. The Special Issue “Interplay between Transcription Factors and Genome Organization” of the International Journal of Molecular Sciences will include original research articles and reviews focusing on these emerging aspects of gene regulation in both normal and disease contexts. Studies using a wide range of genetic, cell biological, molecular, genome-wide, and bioinformatic approaches are encouraged.
Prof. Dr. Giorgio Dieci
Guest Editor
Manuscript Submission Information
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Keywords
- transcription factors
- enhancers
- retrotransposons
- chromatin architectural proteins
- chromosome conformation
- condensates
- 3D genome
- cell identity
