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Special Issue "Interplay between Transcription Factors and Genome Organization"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Genetics and Genomics".

Deadline for manuscript submissions: 28 February 2022.

Special Issue Editor

Prof. Dr. Giorgio Dieci
E-Mail Website
Guest Editor
Department of Chemistry, Life Sciences and Environmental Sustainability, University of Parma, Parco Area delle Scienze 23/A, 43124 Parma, Italy
Interests: eukaryotic RNA polymerases; retrotransposons; transcription factors; gene regulation; chromatin

Special Issue Information

Dear Colleagues,

Transcription factors (TFs) govern cell-type-specific gene expression programs by binding enhancer elements in a sequence-specific manner, thereby ultimately directing activation or repression of specific promoters. In so doing, TFs also exert a profound influence on the three-dimensional (3D) organization of nuclear chromatin, for example, by driving the formation of DNA loops that favor enhancer–promoter contacts. Such contacts occur within larger chromosomal loop structures, formed by the interaction of architectural proteins bound to each of the loop anchors. Compartments and topologically associating domains (TADs) in 3D genome architecture do in turn shape TF activity, so that the interdependency of TF activity and 3D genome organization is increasingly being recognized as a key factor of gene regulation in living cells. Adding to this complexity, general transcription factors (GTFs) which are expressed in virtually all cell types and are usually placed in the proximity of gene transcription start sites (TSS) have recently been shown to also occupy distal enhancer elements and to act as a new player in shaping the 3D genome and the transcription programs which define different cell identities. The Special Issue “Interplay between Transcription Factors and Genome Organization” of the International Journal of Molecular Sciences will include original research articles and reviews focusing on these emerging aspects of gene regulation in both normal and disease contexts. Studies using a wide range of genetic, cell biological, molecular, genome-wide, and bioinformatic approaches are encouraged.

Prof. Dr. Giorgio Dieci
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • transcription factors
  • enhancers
  • retrotransposons
  • chromatin architectural proteins
  • chromosome conformation
  • condensates
  • 3D genome
  • cell identity

Published Papers

This special issue is now open for submission.
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