Journal Browser

Journal Browser

Special Issue "Mechanosensitive Ion Channels in Health and Disease"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: 31 July 2021.

Special Issue Editors

Prof. Dr. Rashid Giniatullin
Guest Editor
A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, P.O.Box 1627/Neulaniementie 2, 70211 Kuopio, Finland
Interests: synaptic transmission; neuronal plasticity; neuron-glia interactions; neuronal networks; purinergic mechanisms; mechanosensitive ion channels; neurotransmitter receptors in health and disease; receptor desensitization; receptor trafficking; modelling of receptor kinetics; mitochondria; reactive oxygen species; molecular and cellular mechanisms of pain and analgesia; migraine; neuroprotection
Special Issues and Collections in MDPI journals
Dr. Jian Shi

Guest Editor
University Academic Fellow; BHF Intermediate Basic Science Research Fellow; Leeds Institute of Cardiovascular & Metabolic Medicine, School of Medicine, University of Leeds
Interests: Mechanosensation; mechanical sensitivity; shear stress; Piezo1 channels; TRPC channels; endothelial cells; vascular smooth muscle cells; ion channel physiology; ion channel pharmacology; ion channel biophysics

Special Issue Information

Dear Colleagues,

Mechanic sensitivity is the fundamental aspect of functioning of all living species. The still intriguing issue is the nature of the special sensors for detection of mechanical forces. For long time the sensitivity to mechanical forces was attributed to different types of membrane proteins ranging from NMDA glutamate receptors to different subtypes of potassium or TRP channels.  

After discovery in 2010, this list was extended as Piezo channels have emerged as the most sensitive mechanotransducers implicated in a huge variety of physiological and pathological functions. These extremely ‘heavy’ proteins are expressed in sensory neurons to detect the touch and implicated in hearing; in endothelial cells, Piezo1 channels sense shear stress to dictate many important functions such as embryonic development, regulation of vascular tone, angiogenesis and atherosclerosis progression;  in red blood cells they serve as the sensors of the shear stress and are closely linked to red blood cell diseases; in myeloid cells Piezo1 channels are essential for innate immunity; in baroreceptors Piezo1 and Piezo2 channels sense blood pressure; in astrocytes they potentially implicated in the development of Alzheimer’s Disease. Notably, apart from natural mechanical forces, Piezo1 channels are sensitive to the chemical agonist, Yoda1. However, the endogenous Piezo1 agonists are not found yet. 

Activation of Piezo channels is tightly coupled to the purinergic signalling as ATP release is extremely sensitive to mechanical stress suggesting an interesting synergy between these two singlling systems.

One issue of high translational importance in view of the coronavirus pandemics, is the role of Piezo channels in lungs as the data on their functional effects in this tissue are very contradictory. Likewise, the contradictory is the role of Piezo channels in cancer development.

This Special Issue ' Mechanosensitive Ion Channels in Health and Disease ' aims to collect reviews and original papers related to the basic functions of different types of mechanosensitive ion channels and translational aspects of these transducers of mechanical forces.

Prof. Dr. Rashid Giniatullin
Dr. Jian Shi
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Mechanobiology
  • mechanical sensitivity
  • Piezo channels
  • TRP channels
  • K2P channels
  • Yoda1
  • substrate mechanics
  • stretching
  • shear stress
  • extracellular matrix

Published Papers

This special issue is now open for submission.
Back to TopTop