Dear Colleagues,

A renaissance in the development of new therapies for sickle cell disease (SCD) is emerging. Many of these therapies have emanated from novel approaches to our understanding of sickle red blood cell biology and new insights into the genesis of sickle cell vaso-occlusive events. A growing number of clinical trials are developing new targets outside the sickle red blood cell with the hopes of mitigating the devasting cascade of physiologic events resulting in end-organ damage. Various new pathophysiologic mechanisms are being recognized, improving our understanding of sickle cell vasculopathy. They include increased inflammation, vascular adhesion, coagulopathy, and nitric oxide dysfunction. Novel and improved therapies remain to be discovered. For this Special Issue entitled “Sickle Cell Disease: From Pathogenesis to Therapies”, we invite papers on the following topics:

1) Role of the endothelium and adhesion in the vasculopathy of sickle cell disease: Implications for disease monitoring and novel therapeutics;

2) Impaired Nitric oxide function and implications for novel therapeutics;

3) Role of coagulopathy and platelet activation in the pathogenesis of SCD vasculopathy: Implications for disease monitoring and novel therapeutics

Assoc. Prof. Dr. Andrew D. Campbell
Dr. Charles Antwi-Boasiako
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• Sickle Cell
• Coagulation
• Adhesion
• Inflammation
• Vasculopathy
• Nitric Oxide