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Special Issue "Brain Mechanisms of Sleep Related Disorders"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".

Deadline for manuscript submissions: closed (30 April 2021).

Special Issue Editors

Dr. Olga Dergacheva
E-Mail Website
Guest Editor
Department of Pharmacology and Physiology, the George Washington University, Washington, DC, USA
Interests: The neurophysiological mechanisms of respiratory and cardiovascular regulation; sleep regulation; sleep-related disorders
Dr. Jhansi Dyavanapalli
E-Mail
Guest Editor
Department of Pharmacology and Physiology, the George Washington University, Washington, DC, USA

Special Issue Information

Dear Colleagues,

Sleep disorders, particularly sleep-related breathing disorders, are highly prevalent disorders that occur in people of all age groups. Severe long-term consequences of these disorders include increased cardiovascular morbidity and mortality, decrement in cognitive function and impaired quality of life.

Although recent studies, using animal models and innovative optogenetic and chemogenetic approaches, made a remarkable progress toward identifying neurotransmitters and pathways associated with pathophysiology of sleep disorders the alteration in the brain mechanisms underlying the pathophysiology of these disorders are still not fully understood. Understanding these mechanisms might provide a foundation for developing novel therapeutic and pharmacological strategies and improve diagnosis, treatment and prevention of sleep disorders. 

This issue of the International Journal of Molecular Sciences will focus on research related to alteration in sleep-wake regulation mechanisms associated with obstructive and central sleep apneas, sleep-disordered breathing, sudden infant death syndrome and other sleep-related disorders.

Dr. Olga Dergacheva
Dr. Jhansi Dyavanapalli
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Molecular and neurophysiological mechanisms of sleep
  • REM sleep
  • Hypothalamus
  • Brainstem
  • Respiration
  • Sleep-related disorders
  • Sleep-disordering breathing
  • Sleep apnea
  • Animal model of sleep apnea
  • Sudden infant death sindrome

Published Papers (1 paper)

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Open AccessReview
Association of Sleep Architecture and Physiology with Depressive Disorder and Antidepressants Treatment
Int. J. Mol. Sci. 2021, 22(3), 1333; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22031333 - 29 Jan 2021
Viewed by 520
Abstract
Sleep problems are frequently associated with the principal diagnostic criteria for many mental disorders. Alterations in the sleep of depressive patients are of high clinical significance because continuous sleep problems raise the chance of relapse, recurrence, or suicide, as well as the need [...] Read more.
Sleep problems are frequently associated with the principal diagnostic criteria for many mental disorders. Alterations in the sleep of depressive patients are of high clinical significance because continuous sleep problems raise the chance of relapse, recurrence, or suicide, as well as the need for augmenting medications. Most antidepressants have been proven to influence the sleep architecture. While some classes of antidepressants improve sleep, others may cause sleep impairment. The successful treatment of depressive disorder also requires an understanding of the effects of antidepressants on sleep. This article briefly reviews the physiology of sleep and the typical alterations in the sleep architecture in depressive patients and updates the different effects of the majority of antidepressants including novel drugs in clinical practice on sleep. The summary of the updated scientific findings of the relationship between depression and sleep disturbances could be clinically beneficial in choosing the best medication for depressive patients with concurrent sleep disorders. Full article
(This article belongs to the Special Issue Brain Mechanisms of Sleep Related Disorders)
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