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Role of Stem Cells in Ophthalmology
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Role of Stem Cells in Ophthalmology

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: closed (31 January 2022) | Viewed by 7218

Special Issue Editor

Dr. Biju B. Thomas

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Guest Editor
USC Roski Eye Institute, University of Southern California Keck School of Medicine, Los Angeles, CA 90033, USA
Interests: retinal degeneration; stem cells; retinal transplantation; retinitis pigmentosa; age-related macular degeneration; glaucoma; diabetic retinopathy

Special Issue Information

Dear Colleagues,

The retina, which consists of the multi-layered neural retina and the mono-layered retinal pigment epithelium (RPE), has limited capacity for regeneration. Common retinal diseases such as age-related macular degeneration (AMD), retinitis pigmentosa (RP), glaucoma, and diabetic retinopathy cause irreversible vision loss. To restore vision, stem cell therapy is particularly attractive because of its potential to replace degenerated or damaged retinal tissue. Recent studies have used embryonic stem cells (hESCs) or induced pluripotent stem cells (iPSCs) as sources for transplantable tissue. We warmly welcome submissions, including original papers and reviews on various cellular therapies for the molecular mechanisms and treatment of retinal dysfunction diseases. This Special Issue focuses on basic research in the growth and differentiation of stem cells into various retinal cell types, targeting of molecular pathways, advanced labelling techniques, use of biomaterals, 3D bioprinting, retinal organoids, and gene editing to induce stem cell differentiation as emerging techniques.

Dr. Biju B. Thomas
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • stem cells
  • retinal diseases
  • molecular pathways
  • biomaterials
  • 3D bioprinting
  • retinal organoids
  • gene editing
  • stem cell differentiation

Published Papers (2 papers)

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Research

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18 pages, 7585 KiB  
Article
A ROCK Inhibitor Promotes Graft Survival during Transplantation of iPS-Cell-Derived Retinal Cells
by Masaaki Ishida, Sunao Sugita, Kenichi Makabe, Shota Fujii, Yoko Futatsugi, Hiroyuki Kamao, Suguru Yamasaki, Noriko Sakai, Akiko Maeda, Michiko Mandai and Masayo Takahashi
Int. J. Mol. Sci. 2021, 22(6), 3237; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22063237 - 22 Mar 2021
Cited by 9 | Viewed by 3656
Abstract
Currently, retinal pigment epithelium (RPE) transplantation includes sheet and single-cell transplantation, the latter of which includes cell death and may be highly immunogenic, and there are some issues to be improved in single-cell transplantation. Y-27632 is an inhibitor of Rho-associated protein kinase (ROCK), [...] Read more.
Currently, retinal pigment epithelium (RPE) transplantation includes sheet and single-cell transplantation, the latter of which includes cell death and may be highly immunogenic, and there are some issues to be improved in single-cell transplantation. Y-27632 is an inhibitor of Rho-associated protein kinase (ROCK), the downstream kinase of Rho. We herein investigated the effect of Y-27632 in vitro on retinal pigment epithelium derived from induced pluripotent stem cells (iPS-RPE cells), and also its effects in vivo on the transplantation of iPS-RPE cell suspensions. As a result, the addition of Y-27632 in vitro showed suppression of apoptosis, promotion of cell adhesion, and higher proliferation and pigmentation of iPS-RPE cells. Y-27632 also increased the viability of the transplant without showing obvious retinal toxicity in human iPS-RPE transplantation into monkey subretinal space in vivo. Therefore, it is possible that ROCK inhibitors can improve the engraftment of iPS-RPE cell suspensions after transplantation. Full article
(This article belongs to the Special Issue Role of Stem Cells in Ophthalmology)
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Review

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19 pages, 953 KiB  
Review
Current Development, Obstacle and Futural Direction of Induced Pluripotent Stem Cell and Mesenchymal Stem Cell Treatment in Degenerative Retinal Disease
by Ming-Cheng Chiang and Edward Chern
Int. J. Mol. Sci. 2022, 23(5), 2529; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms23052529 - 25 Feb 2022
Cited by 5 | Viewed by 2659
Abstract
Degenerative retinal disease is one of the major causes of vision loss around the world. The past several decades have witnessed emerging development of stem cell treatment for retinal disease. Nevertheless, sourcing stem cells remains controversial due to ethical concerns and their rarity. [...] Read more.
Degenerative retinal disease is one of the major causes of vision loss around the world. The past several decades have witnessed emerging development of stem cell treatment for retinal disease. Nevertheless, sourcing stem cells remains controversial due to ethical concerns and their rarity. Furthermore, induced pluripotent stem cells (iPSCs) and mesenchymal stem cells (MSCs) are both isolated from patients’ mature tissues; thus, issues such as avoiding moral controversy and adverse events related to immunosuppression and obtaining a large number of cells have opened a new era in regenerative medicine. This review focuses on the current application and development, clinical trials, and latest research of stem cell therapy, as well as its limitations and future directions. Full article
(This article belongs to the Special Issue Role of Stem Cells in Ophthalmology)
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