Dear Colleagues,

A fungicide is any agent that can prevent, moderate, repel or even kill fungi. Being widely applied as a treatment against both human and plant pathogens as well as a preservative additive for food commodities or for the conservation of porous building materials in monuments, fungicides have undoubtedly become a feature that the environment has to cope with. The mode of action of antifungals is closely related to specific metabolic pathways; however, despite certain similarities between fungi and animals, such mechanisms are frequently difficult to elucidate. Additionally, due to the increase in occurrences of resistance, the beneficial role of known fungicides is rapidly declining, which poses a serious threat to human health and agriculture and creates a vulnerability to fungi in both plants and animals. Today, since new strategies are required to face new problems, it is necessary more than ever to promote investigations focused on the molecular mechanisms surrounding the biological activity of fungicide/fungistatic compounds in order to provide crucial insights on fungicides that could potentially be strategic for their implementation.

In this Special Issue, the most recent scientific advances on the molecular mechanisms behind fungicides’ biological activity, use, physical state, pathophysiological effects and sources will be presented. Research manuscripts and review articles focused on the cellular/molecular mechanisms of fungicide-promoted toxicity in target and non-target organisms, biodegradation, biotransformation and bioaccumulation, innovative formulation technologies, lead projects aimed at the development of new generation antifungal bioactives or overcoming fungicide resistance will be considered.

Prof. Dr. Giorgio Pelosi
Guest Editor

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• Antifungal compounds
• Fungicides
• Bioactives
• Fungal pathogen drug resistance
• Fungal growth inhibitors
• Fungi containment
• Antimicrobial molecules
• Fungal toxic metabolites
• Aflatoxin
• Sterigmatocystin