Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
5.3
4.1
Journals
Metabolites
Special Issues
Metabolomics Analysis of Natural Products Volume II
share announcement

Metabolomics Analysis of Natural Products Volume II

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Advances in Metabolomics".

Deadline for manuscript submissions: closed (15 September 2022) | Viewed by 4515

Special Issue Editors

Dr. María Elena Rodríguez Cabezas

E-Mail Website
Guest Editor
Department of Pharmacology, Instituto de Investigación Biosanitaria de Granada (ibs.GRANADA), Granada, Spain
Interests: antioxidant; intestinal inflammation; microbiota; natural compounds; postbiotics; prebiotics; probiotics
Special Issues, Collections and Topics in MDPI journals
Dr. Alba Rodríguez-Nogales

E-Mail Website
Guest Editor
Department of Pharmacology, Instituto de Investigación Biosanitaria de Granada (ibs.GRANADA), Granada, Spain
Interests: antioxidant; immune response; inflammation; microbiota; polyphenols; prebiotics; probiotics
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Many natural products, such as prebiotics, probiotics, symbiotics or polyphenols, demonstrate biological activities that have a beneficial impact on human health, thus being an important source for the development of novel drugs. These products can affect gut microbiota metabolism, and they promote the production and release of a complex series of end products that can modulate human metabolism and health. However, there is currently a limited understanding of microbiome-natural products and interactions and the metabolites that they produce. In this regard, metabolomics has become an essential tool for studying the detailed mechanisms involved in the effects exerted by these products on microbiomes and their subsequent consequences on human health and disease. Metabolomics is a well-established approach for exploring novel biomarkers of disease diagnosis and prognosis.  Therefore, this Special Issue of Metabolites, “Metabolomics Analysis of Natural Products”, welcomes the submission of manuscripts that either describe original research or review the latest advances in and challenges to natural, product-derived metabolites and microbiome crosstalk. Specific areas include, but not limited to: the identification of novel metabolites with a biological and/or clinical relevance, visualization practices, metabolite annotation, methods for the integrative analysis of microbiomes and natural products derived from metabolite data, and multi-omic approaches to find new molecular prognostic and diagnostic biomarkers. Finally, we also invite manuscripts that focus on innovative and integrative technologies for the discovery and validation of biomarkers. 

This Special Issue is open for submissions now. A proper extension may be granted. Please kindly let us know in advance. Accepted papers will be published continuously in the journal (as soon as they are accepted) and will be listed together on the Special Issue website.

Dr. Maria Elena Rodriguez-Cabezas
Dr. Alba Rodríguez-Nogales
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • probiotics
  • prebiotics
  • polyphenols
  • microbiome
  • metabolome
  • biomarkers

Published Papers (2 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

15 pages, 1740 KiB  
Article
Metabolic Profiling of Heliotropium crispum Aerial Parts Using HPLC and FTIR and In Vivo Evaluation of Its Anti-Ulcer Activity Using an Ethanol Induced Acute Gastric Ulcer Model
by Syeda Farheen Fatima, Saiqa Ishtiaq, Manar O. Lashkar, Fadia S. Youssef, Mohamed L. Ashour and Sameh S. Elhady
Metabolites 2022, 12(8), 750; https://0-doi-org.brum.beds.ac.uk/10.3390/metabo12080750 - 16 Aug 2022
Cited by 5 | Viewed by 1935
Abstract
This study explored the antiulcer potential of methanol extract and fractions of Heliotropium crispum roots against the ethanol-induced gastric ulcer model in rats. Metabolic profiling of H. crispum aerial parts using Fourier-transform infrared spectroscopy (FTIR) revealed the presence of different metabolites with various [...] Read more.
This study explored the antiulcer potential of methanol extract and fractions of Heliotropium crispum roots against the ethanol-induced gastric ulcer model in rats. Metabolic profiling of H. crispum aerial parts using Fourier-transform infrared spectroscopy (FTIR) revealed the presence of different metabolites with various functional groups. Meanwhile, High Performance Liquid Chromatography (HPLC) revealed the presence of three main peaks assigned to myricetin, quercetin, and kaempferol. In vivo, antiulcer activity results showed that the disease control group displayed five tiny ulcers less than 2 mm in diameter in addition to two hemorrhagic streaks. However, in the standard control group, only one small ulcer was visible for the total methanol extract. Gastric tissues and contents were evaluated to determine many parameters such as ulcer score, ulcer index, percentage inhibition of ulcer, gastric pH, gastric juice volume, and acidity. Results were endorsed by histopathological evaluation; gastric pH and mucus content were significantly increased, but gastric juice volume was significantly decreased. All fractions showed a significant decrease in ulcer index and % inhibition except the n-hexane fraction, whose results were insignificant compared to the disease control group. Thus, it was concluded that H. crispum shows an antiulcer effect by decreasing gastric juice volume and acidity, whereas gastric pH and mucus contents were increased that is attributed to the synergistic action of its detected polyphenolic compounds. Full article
(This article belongs to the Special Issue Metabolomics Analysis of Natural Products Volume II)
►▼ Show Figures

Graphical abstract

16 pages, 3179 KiB  
Article
Comparative Metabolomics Reveals Key Determinants in the Flavor and Nutritional Value of Coconut by HS-SPME/GC-MS and UHPLC-MS/MS
by Hao Guo, Jun Lai, Chun Li, Haihong Zhou, Chao Wang, Weizhen Ye, Yue Zhong, Xuecheng Zhao, Feng Zhang, Jun Yang and Shouchuang Wang
Metabolites 2022, 12(8), 691; https://0-doi-org.brum.beds.ac.uk/10.3390/metabo12080691 - 26 Jul 2022
Cited by 5 | Viewed by 2161
Abstract
Coconut is a tropical fruit whose flesh has high flavor quality and nutritional value; however, the differences between coconut varieties are still unclear. Here, volatiles and non-volatiles were profiled at three ripening stages by HS-SPME/GC-MS and UHPLC-MS/MS in two coconut varieties (Hainan Tall, [...] Read more.
Coconut is a tropical fruit whose flesh has high flavor quality and nutritional value; however, the differences between coconut varieties are still unclear. Here, volatiles and non-volatiles were profiled at three ripening stages by HS-SPME/GC-MS and UHPLC-MS/MS in two coconut varieties (Hainan Tall, HT and Green Dwarf, GD). Four metabolite classes of volatiles were associated with good aroma including hydrocarbons, benzenoids, alcohols and esters, and these volatiles were generally higher in GD, especially at 7 and 9 months of coconut growth. Pathway-based metabolomics revealed that flavonols and their derivatives were significantly enriched in HT, and some of these metabolites were key determinants of HT flesh bitterness, including kaempferol 7-O-glucoside, a known bitter metabolite. Despite the overall accumulation of amino acids, including L-alanine, L-serine and L-methionine in GD, comparative metabolomics revealed that HT flesh provides a higher content of vitamins than GD. This study sheds light on the metabolic pathways and key metabolites differentiating the flesh flavor quality and nutritional value among coconut varieties, and reveals the possible mechanisms of flavor formation and regulation in coconut fruits. Full article
(This article belongs to the Special Issue Metabolomics Analysis of Natural Products Volume II)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-2
Back to TopTop