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Nutrients
Special Issues
Probiotics and Their Metabolites in Human Health
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Probiotics and Their Metabolites in Human Health

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Prebiotics and Probiotics".

Deadline for manuscript submissions: 25 October 2024 | Viewed by 1604

Special Issue Editor

Dr. Alba Rodriguez-Nogales

E-Mail Website
Guest Editor
Digestive Unit, Hospital Universitario Virgen de las Nieves, ibs.GRANADA, 18014 Granada, Spain
Interests: polyphenols; antioxidant; immune response; microbiota; probiotics
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Probiotics are live microorganisms that are intended to have health benefits when consumed or applied to the body. These microorganisms colonize the gastrointestinal tract and promote the balance of the intestinal microbiota, thereby strengthening the immune system and improving digestive health. Furthermore, metabolites produced by probiotics, such as short-chain fatty acids and bioactive peptides, act as signaling molecules that regulate a variety of physiological processes, including immune function, energy homeostasis, and intercellular communication. By regulating intestinal permeability and modulating the immune response, probiotics and their metabolites not only promote intestinal health but also show potential to positively influence mental health, cardiovascular health, and other key aspects of human physiology. Therefore, probiotics and their metabolites can influence the body's response to various environmental stimuli and are key in the prevention of chronic diseases and in maintaining human health.

Dr. Alba Rodriguez-Nogales
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • probiotics
  • metabolites
  • microbiome
  • pathologies
  • postbiotics
  • health
  • chronic diseases

Published Papers (1 paper)

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Research

14 pages, 2402 KiB  
Article
Efficacy of Butyrate to Inhibit Colonic Cancer Cell Growth Is Cell Type-Specific and Apoptosis-Dependent
by Sema Oncel, Bryan D. Safratowich, James E. Lindlauf, Zhenhua Liu, Daniel G. Palmer, Mary Briske-Anderson and Huawei Zeng
Nutrients 2024, 16(4), 529; https://0-doi-org.brum.beds.ac.uk/10.3390/nu16040529 - 14 Feb 2024
Viewed by 1404
Abstract
Increasing dietary fiber consumption is linked to lower colon cancer incidence, and this anticancer effect is tied to elevated levels of short-chain fatty acids (e.g., butyrate) because of the fermentation of fiber by colonic bacteria. While butyrate inhibits cancer cell proliferation, the impact [...] Read more.
Increasing dietary fiber consumption is linked to lower colon cancer incidence, and this anticancer effect is tied to elevated levels of short-chain fatty acids (e.g., butyrate) because of the fermentation of fiber by colonic bacteria. While butyrate inhibits cancer cell proliferation, the impact on cancer cell type remains largely unknown. To test the hypothesis that butyrate displays different inhibitory potentials due to cancer cell type, we determined half-maximal inhibitory concentrations (IC50) of butyrate in HCT116, HT-29, and Caco-2 human colon cancer cell proliferation at 24, 48, and 72 h. The IC50 (mM) butyrate concentrations of HCT116, HT-29, and Caco-2 cells were [24 h, 1.14; 48 h, 0.83; 72 h, 0.86], [24 h, N/D; 48 h, 2.42; 72 h, 2.15], and [24 h, N/D; 48 h, N/D; 72 h, 2.15], respectively. At the molecular level, phosphorylated ERK1/2 and c-Myc survival signals were decreased by (>30%) in HCT116, HT-29, and Caco-2 cells treated with 4 mM butyrate. Conversely, butyrate displayed a stronger potential (>1-fold) for inducing apoptosis and nuclear p21 tumor suppressor in HCT116 cells compared to HT-29 and Caco-2 cells. Moreover, survival analysis demonstrated that a cohort with high p21 gene expression in their colon tissue significantly increased survival time compared to a low-p21-expression cohort of colon cancer patients. Collectively, the inhibitory efficacy of butyrate is cell type-specific and apoptosis-dependent. Full article
(This article belongs to the Special Issue Probiotics and Their Metabolites in Human Health)
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