The Impact of Diet, Nutrition, and Lifestyle Habits on Cognition and the Risk of Developing Mild Cognitive Impairment and Dementia

Dear Colleagues,

More than a third of dementia cases could be preventable through the promotion of brain-healthy habits. Lifestyle habits include good adherence to a healthy diet, regular physical exercise, strict control of cardiovascular risk factors, promotion of good socioemotional health and engagement in continuous intellectual activity.

Advancing our understanding of the relationship between lifestyle habits and the risk of cognitive decline, as well as the progression from mild cognitive impairment to dementia, is crucial. It is imperative to understand the magnitude of risk increase or protection associated with each of these factors, and grasp their actual distribution within different populations (individuals at risk of cognitive decline, those with Alzheimer's disease and other causes of cognitive impairment, both in the general population and those with Down syndrome). Additionally, it is essential to comprehend the pathophysiological mechanisms through which these risk and protective factors operate, and assess their potential applicability as therapeutic targets for preventing cognitive decline (both degenerative and non-neurodegenerative) and managing the progression of cognitive impairment once established.

In this Special Issue, contributions focusing on healthy lifestyle habits are welcome, with a particular emphasis on those addressing diet and nutritional supplements in the context of a cognitive decline. Eligible submissions include works with a basic research approach (understanding the relationship between lifestyle habits and pathophysiological mechanisms related to the development of cognitive decline), translational research (the connection between these lifestyle habits, therapeutic strategies focused on promoting brain health and the relation with available biomarkers related with pathologies inducing cognitive decline) and clinical research (evaluating the effectiveness of interventions centered around lifestyle habits to prevent or mitigate cognitive decline). Original research, meta-analyses, systematic reviews and narrative reviews will all be considered.

Dr. Miren Altuna-Azkargorta
Guest Editor

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• lifestyle habits
• diet
• Alzheimer’s disease
• cognitive decline
• dementia
• prevention