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Pharmaceuticals
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Natural Products and Their Modifications as Agents Used in the...
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Natural Products and Their Modifications as Agents Used in the Fight against Pathogens

A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Natural Products".

Deadline for manuscript submissions: 31 July 2024 | Viewed by 2757

Special Issue Editor

Dr. Anna Duda-Madej

E-Mail Website
Guest Editor
Department of Microbiology, Faculty of Medicine, Wroclaw Medical University, Chałubińskiego 4, 50-368 Wrocław, Poland
Interests: flavonoid; natural compounds; biological activity; anticancer activity; antioxidant activity; chalcone; multidrug-resistant pathogens; food science; antimicrobial agents; cytotoxicity assays; amyloid; Crohn’s disease; AIEC; biofilm
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The problem of the resistance of bacterial strains to commercially available antibiotics keeps clinicians around the world awake at night. Therefore, the search for new compounds of natural origin is crucial in solving this problem. It is crucial that these products simultaneously protect the intestinal microbiota, which plays a huge role in maintaining the health of the entire body.     

Various extracts of natural origin show biological activity at a different levels, and at the same time have a protective effect on the intestinal microbiota. It is important to choose such chemical modifications that increase antimicrobial activity, and at the same time support our immune system and have anti-inflammatory and anti-proliferative properties.               

Therefore, articles that compare the biological activity of pathogenic strains and/or intestinal microbiota in the presence of natural compounds/compounds used in medicine in various chemical modifications will be of interest here. Manuscripts examining the effect of plant extracts themselves and pure compounds or their combinations dominant in the plant will also be of interest.              

Extracts and their main components obtained as a result of chemical modifications and biotransformations seem to be the future in the fight against infections caused by multidrug-resistant strains.

Dr. Anna Duda-Madej
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceuticals is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • plant extract
  • natural compounds
  • multidrug-resistant strains
  • intestinal microbiota
  • chemical modyfication
  • biotransformation

Published Papers (3 papers)

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Research

39 pages, 2992 KiB  
Article
Phytochemical Analysis, Biological Activities, and Molecular Docking Studies of Root Extracts from Paeonia Species in Serbia
by Petar Batinić, Aleksandra Jovanović, Dejan Stojković, Gökhan Zengin, Ilija Cvijetić, Uroš Gašić, Natalija Čutović, Mirjana B. Pešić, Danijel D. Milinčić, Tamara Carević, Aleksandar Marinković, Branko Bugarski and Tatjana Marković
Pharmaceuticals 2024, 17(4), 518; https://0-doi-org.brum.beds.ac.uk/10.3390/ph17040518 - 17 Apr 2024
Viewed by 437
Abstract
Without being aware of their chemical composition, many cultures have used herbaceous peony roots for medicinal purposes. Modern phytopreparations intended for use in human therapy require specific knowledge about the chemistry of peony roots and their biological activities. In this study, ethanol–water extracts [...] Read more.
Without being aware of their chemical composition, many cultures have used herbaceous peony roots for medicinal purposes. Modern phytopreparations intended for use in human therapy require specific knowledge about the chemistry of peony roots and their biological activities. In this study, ethanol–water extracts were prepared by maceration and microwave- and ultrasound-assisted extractions (MAE and UAE, respectively) in order to obtain bioactive molecules from the roots of Paeonia tenuifolia L., Paeonia peregrina Mill., and Paeonia officinalis L. wild growing in Serbia. Chemical characterization; polyphenol and flavonoid content; antioxidant, multianti-enzymatic, and antibacterial activities of extracts; and in vitro gastrointestinal digestion (GID) of hot water extracts were performed. The strongest anti-cholinesterase activity was observed in PT extracts. The highest anti-ABTS (2,2′-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) radical potential was observed in PP extracts, whereas against DPPH (2,2-diphenyl-1-picrylhydrazyl radicals), the best results were achieved with PO extracts. Regarding antibacterial activity, extracts were strongly potent against Bacillus cereus. A molecular docking simulation was conducted to gather insights into the binding affinity and interactions of polyphenols and other Paeonia-specific molecules in the active sites of tested enzymes. In vitro GID of Paeonia teas showed a different recovery and behavior of the individual bioactives, with an increased recovery of methyl gallate and digallate and a decreased recovery of paeoniflorin and its derivatives. PT (Gulenovci) and PP (Pirot) extracts obtained by UAE and M were more efficient in the majority of the bioactivity assays. This study represents an initial step toward the possible application of Paeonia root extracts in pharmacy, medicine, and food technologies. Full article
(This article belongs to the Special Issue Natural Products and Their Modifications as Agents Used in the Fight against Pathogens)
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15 pages, 4927 KiB  
Article
Identification of Metabolites from Catharanthus roseus Leaves and Stem Extract, and In Vitro and In Silico Antibacterial Activity against Food Pathogens
by Qazi Mohammad Sajid Jamal and Varish Ahmad
Pharmaceuticals 2024, 17(4), 450; https://0-doi-org.brum.beds.ac.uk/10.3390/ph17040450 - 30 Mar 2024
Viewed by 723
Abstract
The plant produced powerful secondary metabolites and showed strong antibacterial activities against food-spoiling bacterial pathogens. The present study aimed to evaluate antibacterial activities and to identify metabolites from the leaves and stems of Catharanthus roseus using NMR spectroscopy. The major metabolites likely to [...] Read more.
The plant produced powerful secondary metabolites and showed strong antibacterial activities against food-spoiling bacterial pathogens. The present study aimed to evaluate antibacterial activities and to identify metabolites from the leaves and stems of Catharanthus roseus using NMR spectroscopy. The major metabolites likely to be observed in aqueous extraction were 2,3-butanediol, quinic acids, vindoline, chlorogenic acids, vindolinine, secologanin, and quercetin in the leaf and stem of the Catharanthus roseus. The aqueous extracts from the leaves and stems of this plant have been observed to be most effective against food spoilage bacterial strains, followed by methanol and hexane. However, leaf extract was observed to be most significant in terms of the content and potency of metabolites. The minimum inhibitory concentration (20 µg/mL) and bactericidal concentrations (35 g/mL) of leaf extract were observed to be significant as compared to the ampicillin. Molecular docking showed that chlorogenic acid and vindolinine strongly interacted with the bacterial penicillin-binding protein. The docking energies of chlorogenic acid and vindolinine also indicated that these could be used as food preservatives. Therefore, the observed metabolite could be utilized as a potent antibacterial compound for food preservation or to treat their illness, and further research is needed to perform. Full article
(This article belongs to the Special Issue Natural Products and Their Modifications as Agents Used in the Fight against Pathogens)
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15 pages, 1865 KiB  
Article
HPLC-DAD Analysis and Investigation of Biological Properties of the Leaves of Globularia alypum (L.), Infusion Extract
by Sahar Nouir, Aicha Laouani, Ahmed Loghmari, Khaireddine Bouassida, Raoudha Slim, Rim Bouhajeb, Yosra Hasni, Khaled Saguem, Bouraoui Ouni and Amira Zaïri
Pharmaceuticals 2023, 16(12), 1726; https://0-doi-org.brum.beds.ac.uk/10.3390/ph16121726 - 14 Dec 2023
Viewed by 1023
Abstract
Globularia alypum L. (GA) belonging to the Globulariaceae family is a Mediterranean plant which is widely used in traditional Tunisian medicine. The aim of this study was to investigate the phytochemical composition, antioxidant, anti-arthritic, antiproliferative, antibacterial and antibiofilm potential of aqueous GA leaf [...] Read more.
Globularia alypum L. (GA) belonging to the Globulariaceae family is a Mediterranean plant which is widely used in traditional Tunisian medicine. The aim of this study was to investigate the phytochemical composition, antioxidant, anti-arthritic, antiproliferative, antibacterial and antibiofilm potential of aqueous GA leaf extracts (AGAL). Quantitative analyses of the different constituents of extracts were evaluated by high-performance liquid chromatography with photodiode-array detection (HPLC-DAD). Spectrophotometric methods and chemical tests were used for antioxidant and anti-arthritic activities. The antiproliferative study was evaluated using colorectal cancer SW620 cells, while the antibacterial assessment and analysis of the antibiofilm effects were determined by the microdilution method and the crystal violet assay, respectively. AGAL extracts presented several components, mainly Nepetin-7-Glucoside and trans-ferrulic acid. The results showed that they had an important antioxidant (IC50 = 0.34; 0.38 and 1.20 mg/mL) and anti-arthritic (IC50 = 2.94 mg/mL) properties, and these effects are displayed in a dose-dependent manner. In addition, this extract demonstrated significant antiproliferative (IC50 = 50 µg/mL), antibacterial (MIC = 6.25 mg/mL and MBC = 6.25 mg/mL), and antibiofilm (59.70% at 25 mg/mL) properties especially against S. aureus. The results achieved confirm the important role of this plant as a source of therapeutic activities. Full article
(This article belongs to the Special Issue Natural Products and Their Modifications as Agents Used in the Fight against Pathogens)
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