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Antimicrobial Agents: Natural Products or Synthetic Compounds

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Microbiology".

Deadline for manuscript submissions: 15 August 2024 | Viewed by 881

Special Issue Editor


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Guest Editor
Department of Microbiology, Faculty of Medicine, Wroclaw Medical University, Chałubińskiego 4, 50-368 Wrocław, Poland
Interests: flavonoid; natural compounds; biological activity; anticancer activity; antioxidant activity; chalcone; multidrug-resistant pathogens; food science; antimicrobial agents; cytotoxicity assays; amyloid; Crohn’s disease; AIEC; biofilm
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Special Issue Information

Dear Colleagues,

In the era of widespread multidrug resistance amongst various microorganisms, it is important to search for new compounds with the etiology of multidrug-resistant strains that can effectively protect against infections.

We can ask ourselves whether such compounds are “gifts of nature”, that is, commonly available natural compounds. Maybe their derivatives are created by various chemical modifications, perhaps artificially synthesized compounds, or modifications of already existing compounds, such as antibiotics? Is there a possible pathway that uses a combination of substances from the above-mentioned groups, and which pathway will prove to be the best?

This Special Issue welcomes papers that address the above questions. Manuscripts that will bring us closer to developing an effective product in the fight against infectious diseases with multidrug-resistant strains will be considered.

Dr. Anna Duda-Madej
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • natural products
  • multidrug resistance
  • antimicrobial agents
  • synthetic compounds
  • infectious diseases

Published Papers (1 paper)

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Research

15 pages, 3505 KiB  
Article
Harnessing Nature’s Defence: The Antimicrobial Efficacy of Pasteurised Cattle Milk-Derived Extracellular Vesicles on Staphylococcus aureus ATCC 25923
by Dulmini Nanayakkara Sapugahawatte, Kasun Godakumara, Mihkel Mäesaar, Gayandi Ekanayake, Getnet Balcha Midekessa, Madhusha Prasadani, Suranga Kodithuwakku, Mati Roasto, Aneta Andronowska and Alireza Fazeli
Int. J. Mol. Sci. 2024, 25(9), 4759; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms25094759 - 26 Apr 2024
Viewed by 699
Abstract
Increasing antimicrobial resistance (AMR) challenges conventional antibiotics, prompting the search for alternatives. Extracellular vesicles (EVs) from pasteurised cattle milk offer promise, due to their unique properties. This study investigates their efficacy against five pathogenic bacteria, including Staphylococcus aureus ATCC 25923, aiming to combat [...] Read more.
Increasing antimicrobial resistance (AMR) challenges conventional antibiotics, prompting the search for alternatives. Extracellular vesicles (EVs) from pasteurised cattle milk offer promise, due to their unique properties. This study investigates their efficacy against five pathogenic bacteria, including Staphylococcus aureus ATCC 25923, aiming to combat AMR and to develop new therapies. EVs were characterised and tested using various methods. Co-culture experiments with S. aureus showed significant growth inhibition, with colony-forming units decreasing from 2.4 × 105 CFU/mL (single dose) to 7.4 × 104 CFU/mL (triple doses) after 12 h. Milk EVs extended lag time (6 to 9 h) and increased generation time (2.8 to 4.8 h) dose-dependently, compared to controls. In conclusion, milk EVs exhibit dose-dependent inhibition against S. aureus, prolonging lag and generation times. Despite limitations, this suggests their potential in addressing AMR. Full article
(This article belongs to the Special Issue Antimicrobial Agents: Natural Products or Synthetic Compounds)
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