Liposomal Drug Delivery Systems
A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Delivery and Controlled Release".
Deadline for manuscript submissions: closed (10 January 2022) | Viewed by 44457
Special Issue Editors
Interests: liposome; drug delivery; solubility enhancement; stimuli sensitive; dual-targeting; cyclodextrin-in-liposome
Interests: liposome; drug delivery; solubility enhancement; stimuli sensitive; dual-targeting; cyclodextrin-in-liposome
Special Issue Information
Dear Colleagues,
It is recognized that the effectiveness of certain drugs is impeded by several challenges, such as poor water solubility, instability, antigenicity, toxicity, inability to cross cell-membrane barriers, low bioavailability, and/or rapid clearance.
One of the strategies available to improve the pharmacokinetic and pharmacodynamic properties of drugs is the use of nanotechnology-based drug delivery systems.
Liposomes have the unique ability to entrap both lipophilic and hydrophilic compounds, enabling a diverse range of drugs to be encapsulated by these vesicles. Furthermore, the large aqueous center and biocompatible lipid bilayer permit the delivery of a variety of macromolecules, such as DNA, proteins, and imaging agents. Because of this, they have been shown to be beneficial for stabilizing therapeutic compounds, overcoming obstacles to cellular and tissue uptake, improving the biodistribution of compounds to target sites in vivo, and enabling the effective delivery of encapsulated compounds to target sites while minimizing systemic toxicity.
The encapsulation of drugs in liposomes is a tremendously challenging task that is continuously evolving. Studies containing drug-in-cyclodextrin-in-liposome formulations, co-delivery of drugs from these nanosystems, gelation of the internal core of liposomes, or liposomes containing drug nanocrystals are exploited strategies for stabilization, solubility enhancement, and modified drug delivery. Interesting challenges and current approaches toward different administration routes (oral, pulmonary, topical, etc.) are being investigated. Additionally, stimuli-sensitive liposomes are investigated as drug delivery systems in combination with local physiological stimuli for several diseases. In this field, chemo-photothermal synergetic antitumor drug delivery systems using gold derivative compounds have been exploited. Ligand-modified liposomes by dual-targeting strategies are also beneficial for tumor-specific drug delivery.
We kindly invite you to submit full papers, communications, and reviews regarding the above-described topics, dealing with all aspects of liposomes as drug delivery systems.
Prof. Dr. Antonio María Rabasco Álvarez
Prof. Dr. María Luisa González Rodríguez
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.