Special Issue "New Strategies for the Reduction of Uremic Toxins"
Deadline for manuscript submissions: closed (31 January 2021).
Interests: biomarkers of CKD; uremic toxins; microbiota; probiotics; proteomics
The accumulation of organic waste products, i.e., so-called uremic toxins, that are normally cleared by the kidneys characterizes chronic kidney disease (CKD). First of all, along with a number of known and unknown toxic metabolites, urea have the potential to dysregulate cellular functions in kidney and other organs when patients suffer from an illness known as uremia. It is increasingly evident that uremic toxins influence nontraditional risk factors, such as inflammation and endothelial dysfunction, contributing to cardiovascular (CV) damage in CKD. Particularly, protein-bound uremic toxins seem to play an increasing role in the incidence of CV disease in CKD, as well as in blood pressure regulation and hypertension. This is due to the high binding affinity of these metabolites to serum proteins, which makes them not efficently removable via conventional hemodialysis and causes their progressive accumulation in CKD patients, leading to disease progression and resulting in organ damage. Indeed, in the general population, death from CV disease accounts for approximately one in 1000 people per year (6%–13% of all deaths), whereas among CKD patients, it accounts for 59 in 1000 people per year (26% of total mortality). Therefore, strategies aimed at lowering uremic toxins are strongly desirable, in order to reach clinical benefit in terms of slowing the progression of CKD and preventing CV disease.
Dr. Maria Teresa Rocchetti
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a double-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxins is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- uremic toxins
- chronic kidney disease
- cardiovascular risk
- gut microbiota
- indoxyl sulfate
- p-cresyl sulfate