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Novel Extracellular and Intracellular Signalling Mechanisms in Bone 3.0
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Novel Extracellular and Intracellular Signalling Mechanisms in Bone 3.0

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: closed (31 March 2023) | Viewed by 1609

Special Issue Editors

Prof. Dr. Hyung-Mun Yun

E-Mail Website
Guest Editor
Department of Oral Maxillofacial Pathology, School of Dentistry, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Republic of Korea
Interests: molecular and cellular pathology; 5-hydroxytryptamine; differentiation; regeneration; bone; CNS
Special Issues, Collections and Topics in MDPI journals
Dr. Kyung-Ran Park

E-Mail Website
Guest Editor
Korea Basic Science Institute (KBSI), Natural Science Campus, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul 02841, Republic of Korea
Interests: stem cell; differentiation; regeneration; bone development
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Bone is influenced by environmental and genetic factors and numerous local and systemic regulators. Molecular and cellular studies have identified mechanisms in various stem cells and specialized bone cells that affect bone development, bone maintenance, and bone regeneration. Impaired bone metabolisms induce exaggerated bone loss in patients with diseases characterized by decreased bone mass and increased risk of fractures. This Special Issue focuses on novel extracellular and intracellular signaling mechanisms contributing to bone morphogenesis, bone formation, bone remodeling, and bone diseases. We warmly welcome submissions, including original papers and reviews, on this widely discussed topic.

Prof. Dr. Hyung-Mun Yun
Dr. Kyung-Ran Park
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bone formation
  • bone remodeling
  • bone disease
  • osteoclast

Published Papers (1 paper)

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Research

12 pages, 2603 KiB  
Article
Suffruticosol B Is an Osteogenic Inducer through Osteoblast Differentiation, Autophagy, Adhesion, and Migration
by Hyung-Mun Yun, Joon Yeop Lee, Bomi Kim and Kyung-Ran Park
Int. J. Mol. Sci. 2022, 23(21), 13559; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms232113559 - 04 Nov 2022
Viewed by 1277
Abstract
Suffruticosol B (Suf-B) is a stilbene found in Paeonia suffruticosa ANDR., which has been traditionally used in medicine. Stilbenes and their derivatives possess various pharmacological effects, such as anticancer, anti-inflammatory, and anti-osteoporotic activities. This study aimed to explore the bone-forming activities and mechanisms [...] Read more.
Suffruticosol B (Suf-B) is a stilbene found in Paeonia suffruticosa ANDR., which has been traditionally used in medicine. Stilbenes and their derivatives possess various pharmacological effects, such as anticancer, anti-inflammatory, and anti-osteoporotic activities. This study aimed to explore the bone-forming activities and mechanisms of Suf-B in pre-osteoblasts. Herein, >99.9% pure Suf-B was isolated from P. suffruticosa methanolic extracts. High concentrations of Suf-B were cytotoxic, whereas low concentrations did not affect cytotoxicity in pre-osteoblasts. Under zero levels of cytotoxicity, Suf-B exhibited bone-forming abilities by enhancing alkaline phosphatase enzyme activities, bone matrix calcification, and expression levels with non-collagenous proteins. Suf-B induces intracellular signal transduction, leading to nuclear RUNX2 expression. Suf-B-stimulated differentiation showed increases in autophagy proteins and autophagosomes, as well as enhancement of osteoblast adhesion and transmigration on the ECM. These results indicate that Suf-B has osteogenic qualities related to differentiation, autophagy, adhesion, and migration. This also suggests that Suf-B could have a therapeutic effect as a phytomedicine in skeletal disorders. Full article
(This article belongs to the Special Issue Novel Extracellular and Intracellular Signalling Mechanisms in Bone 3.0)
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