Dear Colleagues,

You are invited to submit original research articles and reviews that summarize state-of-the-art and future applications for a new Special Issue entitled “The Role of Natural Bioactive Compounds in Healthy Aging and Regenerative Medicine”.

Natural bioactive compounds (NBCs) are physiologically active constituents present in minimal quantities in plant products and in lipid-rich foods. They have been extensively studied to assess their beneficial health effects. Several in vitro, in vivo (animal and human studies), and clinical studies indicate that NBCs participate in the maintenance of human health mainly through their antioxidant and anti-inflammatory actions. Therefore, the increasing demand for NBCs deserves further in-depth investigation and supports the search for new sources of these compounds.

Some of the most important bioactive components found in fruits, vegetables, grains, herbs, seeds and even algae have been shown to substantially affect the lifespan of humans, including the delay or prevention of many age-related diseases, such as neurodegenerative diseases, cardiovascular diseases, cancer, immune system disorders, and musculoskeletal disorders.

Moreover, several bioactive compounds have been shown to promote stem cell migration and lineage-specific differentiation, thus offering novel therapeutic options for regenerative medicine.

This Special Issue aims to provide a forum collection of the latest studies on NBCs and their biological activities, with a view to a possible therapeutic application for age-related disease, particularly for cardiovascular and bone health. In addition, progresses in the field of NBC’s role in stem cells and regenerative medicine will be examined.

We are interested in submissions of original research papers and review articles, including basic research, clinical research, development and application of translational medicine, meta-analyses, commentaries, and reviews.

Dr. Natalia Di Pietro
Dr. Caterina Pipino
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• natural bioactive compounds
• age-related diseases
• cardiovascular diseases
• endothelial dysfunction
• inflammation
• oxidative stress
• atherosclerosis
• hypertension
• obesity
• dyslipidemia
• bone remodeling
• bone formation
• bone resorption
• osteoporosis
• osteoblasts
• osteoclasts
• healthy aging
• regenerative medicine