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Antimicrobial Peptides and Marine Microbe

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Microbiology".

Deadline for manuscript submissions: closed (30 November 2023) | Viewed by 746

Special Issue Editor


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Guest Editor
Department of Cell Biology and Histology, Faculty of Biology, Campus Regional de Excelencia Internacional “Campus Mare Nostrum”, University of Murcia, 30100 Murcia, Spain
Interests: fish, immunology; virus, AMPs; toxicology; cell lines; vaccines; aquaculture; biotechnology
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Special Issue Information

Dear Colleagues,

Antimicrobial peptides (AMPs) have improved our capacity to generate novel treatments against infectious disease of variable pathogens such as bacteria, viruses, fungi, and parasites because of their ability to disrupt their membranes or capsid and kill them directly. In addition, they do not generate resistance and are critical factors in innate immune response since they are key players in the regulation of several immune responses, including the specific response. Thus, antimicrobial peptides are promising candidates as potential therapeutic molecules, although their molecular mechanisms of action are not completely understood yet. This issue invites studies identifying novel and known AMPs from aquatic origin; characterizing their immunomodulatory potential and mechanisms at the cellular and molecular level, as well as their antimicrobial role against marine pathogens for different hosts.

Reviews and original studies are wellcomed. Special attention will be paid to potential applications of the AMPs agains marine microbes. The outcome of the studies collected here will represent a further step in our comprehension of the AMP identification, characterisation and application against marine pathogens.

Dr. Alberto Cuesta
Guest Editor

Manuscript Submission Information

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Keywords

  • antimicrobial peptides
  • immunity
  • aquatic organisms
  • aquaculture
  • marine pathogens
  • bacteria
  • virus
  • parasites
  • biotechnology

Published Papers (1 paper)

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Research

14 pages, 1716 KiB  
Article
Genomic Insights and Synthetic Biology Applications of Marine Actinomycete Streptomyces griseoincarnatus HNS054
by Qinghua Wang, Jing Zhao, Zhaoyuan Liu, Shaoxiong Ding, Zhiyong Huang and Jun Chen
Int. J. Mol. Sci. 2024, 25(6), 3127; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms25063127 - 08 Mar 2024
Viewed by 497
Abstract
The marine bacterium Streptomyces sp. HNS054 shows promise as a platform for producing natural products. Isolated from a marine sponge, HNS054 possesses several desirable traits for bioengineering: rapid growth, salt tolerance, and compatibility with genetic tools. Its genome contains 21 potential biosynthetic gene [...] Read more.
The marine bacterium Streptomyces sp. HNS054 shows promise as a platform for producing natural products. Isolated from a marine sponge, HNS054 possesses several desirable traits for bioengineering: rapid growth, salt tolerance, and compatibility with genetic tools. Its genome contains 21 potential biosynthetic gene clusters, offering a rich source of natural products. We successfully engineered HNS054 to increase the production of aborycin and actinorhodin by 4.5-fold and 1.2-fold, respectively, compared to S. coelicolor M1346 counterparts. With its unique features and amenability to genetic manipulation, HNS054 emerges as a promising candidate for developing novel marine-derived drugs and other valuable compounds. Full article
(This article belongs to the Special Issue Antimicrobial Peptides and Marine Microbe)
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