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Dear Colleagues,

Inflamm-aging is the term used to refer to the chronic low-grade inflammation that develops during aging and accompanies both the development of chronic diseases (e.g., cancer, diabetes, cardiovascular disease, neurodegeneration) and functional decline in older adults. Derangements in cellular quality control systems are responsible for the accrual of intracellular “waste” (e.g., protein aggregates, damaged mitochondria, lipofuscin) and represent candidate mechanisms for the development of inflamm-aging. Indeed, many of these molecules have pro-inflammatory natures and can be released at the systemic level unless efficiently cleared. The mechanisms that regulate the displacement of these molecules are among the processes that must be tackled for the development of anti-inflammatory strategies. Additional molecular pathways that become dysregulated during aging may actively contribute to local and systemic inflammation and thus warrant investigation.

This Special Issue aims to gather contributions from researchers in the field of biogerontology and geroscience who are investigating anti-aging remedies and personalized anti-inflammatory interventions to extend one’s health- and lifespan.

We invite you to submit your latest original research or review articles to this Special Issue.

Dr. Emanuele Marzetti
Dr. Anna Picca
Guest Editors

Manuscript Submission Information

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Related Special Issue

Published Papers (1 paper)

Research

12 pages, 1979 KiB

Open AccessArticle

Cistanche deserticola Polysaccharide Reduces Inflammation and Aging Phenotypes in the Dermal Fibroblasts through the Activation of the NRF2/HO-1 Pathway

by Kento Takaya, Toru Asou and Kazuo Kishi

Int. J. Mol. Sci. 2023, 24(21), 15704; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms242115704 - 28 Oct 2023

Viewed by 943

Abstract

Dermal fibroblasts maintain the skin homeostasis by interacting with the epidermis and extracellular matrix. Their senescence contributes to functional defects in the skin related to aging. Therefore, there is an urgent need for novel therapeutic agents that could inhibit fibroblast senescence. In this study, we investigated the effects of Cistanche deserticola polysaccharide (CDP), a natural anti-inflammatory component, on the progression of senescence in human dermal fibroblasts. Normal human dermal fibroblasts (NHDFs) were cultured in passages, and highly senescent cells were selected as senescent cells. CDP treatment increased the cell proliferation in senescent NHDFs and decreased the proportion of senescence-associated-β-galactosidase-positive cells. The treatment suppressed the senescence-related secretory phenotype, and reactive oxygen species (ROS) production was reduced, alleviating H₂O₂-induced oxidative stress. CDP mitigated ROS formation via the nuclear factor erythroid 2-related factor/heme oxygenase-1 pathway in senescent cells and was involved in the suppression of upstream p-extracellular signal-regulated kinase. These results indicate that CDP is an antioxidant that can alleviate age-related inflammation and may be a useful compound for skin anti-aging. Full article

(This article belongs to the Special Issue Advances in Anti-aging Treatment Development 2.0)

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