Special Issue "Pathogenesis and Treatment of Autism Spectrum Disorders"
Deadline for manuscript submissions: closed (30 April 2021).
Interests: autism spectrum disorders; polyunsaturated fatty acids; signaling mediators, arachidonic acid; DHA; EPA; oxidative stress; total antioxidant power, medical care; mTOR signaling; rapamycin inhibitors
There are most interesting and important findings on pathophysiology of autism related to pharmacological care: (1) α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors can be a potential target for the treatment of social behavior deficits in autism spectrum disorders (ASD); (2) The Rho family GTPases-activating proteins transduce the upstream signals to downstream effectors, thus regulating diverse cellular processes, such as growth, migration, adhesion, and differentiation. In particular, Rho GTPases play essential roles in regulating neuronal morphology and function; (3) The pharmaceutical value of gut peptide hormones in alleviating autism-associated behavioral syndromes will be discussed to provide new insights for future drug development; (4) Perturbation of these processes of mRNA targeting and local protein synthesis in stem cell-derived neurons may synapse development and functions related to cognitive deficits in ASD.
The investigation of links between the ratio of omega-3/omega-6 PUFAs and neuronal signaling is a research priority in autism spectrum disorders (ASD). Increased plasma DHA/arachidonic acid (AA) ratios may induce low plasma levels of ceruloplasmin. Reduced plasma ceruloplasmin levels may diminish the protective capacity against brain damage, contributing to the pathophysiology of social symptoms in individuals with ASD. Also, large doses of AA added to DHA improved ASD social impairment with increased plasma ceruloplasmin levels.
Prof. Dr. Kunio Yui
Manuscript Submission Information
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- arachidonic acid
- signaling mediators
- social impairment
- drug targets