Submit to IJMS Review for IJMS Propose a Special Issue

Journal Menu

Journal Browser

Latest Advancements in Aging and Longevity: Is There a Role for Precision Medicine?

Special Issue Editors
Special Issue Information
Keywords
Published Papers

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pharmacology".

Deadline for manuscript submissions: closed (30 September 2023) | Viewed by 5844

Share This Special Issue

Special Issue Editors

Prof. Dr. Calogero Caruso

E-Mail Website
Guest Editor

Laboratory of Immunopathology and Immunosenescence, Department of Biomedicine, Neuroscience and Advanced Diagnostics, University of Palermo, 90134 Palermo, Italy
Interests: ageing; age-related diseases; centenarians; immunogenetics; immunosenescence; inflammation; longevity; successful ageing; unsuccessful ageing
Special Issues, Collections and Topics in MDPI journals

Prof. Dr. Giuseppina Candore

E-Mail Website
Guest Editor

Laboratory of Immunopathology and Immunosenescence, Department of Biomedicine, Neurosciences and Advanced Diagnostics, University of Palermo, 90134 Palermo, Italy
Interests: autoimmunity; immune response; immunogenetics; immunosenescence; inflamm-aging; immunopathology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Age is the leading predictor of several chronic diseases that account for most of the morbidity, hospitalizations, healthcare costs, and mortality worldwide. It is also the main risk of frailty and reduced physical resilience, with incomplete recovery from stressors. Recently, new breakthroughs have been made in ageing research that might have practical application for treatment and/or prevention, such as senolytic drugs to eliminate senescent cells or young blood with rejuvenating properties. However, most medical treatments and/or preventative measures are designed for the average individual with a one-size-fits-all approach. Thus, some people may not benefit from treatment and/or prevention measures. Precision medicine, also called personalized medicine, is an approach which, to personalize the prevention and treatment of diseases, considers the differences in people genetics, environment, and lifestyle, since each one is unique, the result of its heritage genetics and his/her life experiences.

Precision medicine can also be applied to ageing, to treat/prevent age-related diseases, thus promoting successful ageing and longevity. In fact, everyone ages differently, with different risk factors due to genetics, epigenetics, gender and sex, socio-economic and educational status, chance and life circumstances, nutrition and physical activity, stress management and social support, load pathogen.

Different combinations of these factors create the possibility of becoming susceptible (unsuccessful ageing) to age-related diseases or avoiding them (successful ageing and longevity).

The precision medicine model applied to ageing will be able to lead to new advances in the prevention and treatment of unsuccessful ageing, creating individualized risk profiles that can be linked to a personalized intervention plan. Moreover, customized approach could lead to a diagnostic system that allows precision solutions to be identified and implemented to determine successful ageing and longevity.

In this Special Issue, studies on the different aspects previously mentioned are welcome. Original research papers and reviews concerning either humans or models are equally welcome.

Prof. Dr. Calogero Caruso
Prof. Dr. Giuseppina Candore
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

ageing
age-related diseases
breakthroughs in ageing
hallmarks of ageing
longevity
markers
prevention
risk factors
treatment

Published Papers (3 papers)

Download All Papers

Research

Jump to: Review

14 pages, 2741 KiB

Open AccessArticle

USP15-USP7 Axis and UBE2T Differential Expression May Predict Pathogenesis and Poor Prognosis in De Novo Myelodysplastic Neoplasm

by Luiz Gustavo Almeida de Carvalho, Tatiana Takahasi Komoto, Daniel Antunes Moreno, João Vitor Caetano Goes, Roberta Taiane Germano de Oliveira, Mayara Magna de Lima Melo, Mariela Estefany Gislene Vera Roa, Paola Gyuliane Gonçalves, Carlos Victor Montefusco-Pereira, Ronald Feitosa Pinheiro and Howard Lopes Ribeiro Junior

Int. J. Mol. Sci. 2023, 24(12), 10058; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms241210058 - 13 Jun 2023

Cited by 1 | Viewed by 1297

Abstract

The aim of this study was to evaluate the expression of USP7, USP15, UBE2O, and UBE2T genes in Myelodysplastic neoplasm (MDS) to identify possible targets of ubiquitination and deubiquitination in MDS pathobiology. To achieve this, eight datasets from the Gene Expression Omnibus (GEO) database were integrated, and the expression relationship of these genes was analyzed in 1092 MDS patients and healthy controls. Our results showed that UBE2O, UBE2T, and USP7 were upregulated in MDS patients compared with healthy individuals, but only in mononucleated cells collected from bone marrow samples (p < 0.001). In contrast, only the USP15 gene showed a downregulated expression compared with healthy individuals (p = 0.03). Additionally, the upregulation of UBE2T expression was identified in MDS patients with chromosomal abnormalities compared with patients with normal karyotypes (p = 0.0321), and the downregulation of UBE2T expression was associated with MDS hypoplastic patients (p = 0.033). Finally, the USP7 and USP15 genes were strongly correlated with MDS (r = 0.82; r2 = 0.67; p < 0.0001). These findings suggest that the differential expression of the USP15-USP7 axis and UBE2T may play an important role in controlling genomic instability and the chromosomal abnormalities that are a striking characteristic of MDS. Full article

(This article belongs to the Special Issue Latest Advancements in Aging and Longevity: Is There a Role for Precision Medicine?)

► Show Figures

Figure 1

Review

Jump to: Research

20 pages, 597 KiB

Open AccessReview

Senotherapeutics to Counteract Senescent Cells Are Prominent Topics in the Context of Anti-Ageing Strategies

by Anna Calabrò, Giulia Accardi, Anna Aiello, Calogero Caruso, Damiano Galimberti and Giuseppina Candore

Int. J. Mol. Sci. 2024, 25(3), 1792; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms25031792 - 01 Feb 2024

Viewed by 2319

Abstract

Cellular senescence is implicated in ageing and associated with a broad spectrum of age-related diseases. Importantly, a cell can initiate the senescence program irrespective of the organism’s age. Various stress signals, including those defined as ageing hallmarks and alterations leading to cancer development, oncogene activation, or loss of cancer-suppressive functions, can trigger cellular senescence. The primary outcome of these alterations is the activation of nuclear factor (NF)-κB, thereby inducing the senescence-associated secretory phenotype (SASP). Proinflammatory cytokines and chemokines, components of this phenotype, contribute to chronic systemic sterile inflammation, commonly referred to as inflamm-ageing. This inflammation is linked to age-related diseases (ARDs), frailty, and increased mortality in older individuals. Additionally, senescent cells (SCs) accumulate in multiple tissues with age and are believed to underlie the organism functional decline, as demonstrated by models. An escalating effort has been dedicated to identify senotherapeutics that selectively target SCs by inducing apoptosis; these drugs are termed senolytics. Concurrently, small molecules that suppress senescent phenotypes without causing cell death are known as senomorphics. Both natural and synthetic senotherapeutics, along with immunotherapies employing immune cell-mediated clearance of SCs, currently represent the most promising strategies to combat ageing and ARDs. Indeed, it is fascinating to observe that information regarding the immune reaction to SCs indicates that regulation by specific lymphocyte subsets, elevated in the oldest centenarians, plays a role in attaining extreme longevity. Regardless, the application of methods already utilized in cancer treatment, such as CAR cells and monoclonal antibodies, broadens the spectrum of potential approaches to be utilized. Full article

(This article belongs to the Special Issue Latest Advancements in Aging and Longevity: Is There a Role for Precision Medicine?)

► Show Figures

Figure 1

27 pages, 7455 KiB

Open AccessReview

Targeting Protein Aggregates with Natural Products: An Optional Strategy for Neurodegenerative Diseases

by Lingzhi Xiang, Yanan Wang, Shenkui Liu, Beidong Liu, Xuejiao Jin and Xiuling Cao

Int. J. Mol. Sci. 2023, 24(14), 11275; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms241411275 - 10 Jul 2023

Cited by 2 | Viewed by 1640

Abstract

Protein aggregation is one of the hallmarks of aging and aging-related diseases, especially for the neurodegenerative diseases (NDs) such as Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s disease (HD), Amyotrophic lateral sclerosis (ALS), and others. In these diseases, many pathogenic proteins, such as amyloid-β, tau, α-Syn, Htt, and FUS, form aggregates that disrupt the normal physiological function of cells and lead to associated neuronal lesions. Protein aggregates in NDs are widely recognized as one of the important targets for the treatment of these diseases. Natural products, with their diverse biological activities and rich medical history, represent a great treasure trove for the development of therapeutic strategies to combat disease. A number of in vitro and in vivo studies have shown that natural products, by virtue of their complex molecular scaffolds that specifically bind to pathogenic proteins and their aggregates, can inhibit the formation of aggregates, disrupt the structure of aggregates and destabilize them, thereby alleviating conditions associated with NDs. Here, we systematically reviewed studies using natural products to improve disease-related symptoms by reducing or inhibiting the formation of five pathogenic protein aggregates associated with NDs. This information should provide valuable insights into new directions and ideas for the treatment of neurodegenerative diseases. Full article

(This article belongs to the Special Issue Latest Advancements in Aging and Longevity: Is There a Role for Precision Medicine?)

► Show Figures