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Special Issue "Molecular Mechanism of Anti-inflammatory Actions of Natural Components"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".

Deadline for manuscript submissions: 31 December 2021.

Special Issue Editors

Prof. Dr. Jae Youl Cho
E-Mail Website
Guest Editor
Department of Integrative Biotechnology, Director, Institute of Biomolecule Control, Sungkyunkwan University, 2066 Seobu-ro, Suwon 16419, Korea
Interests: inflammation; cancer; signal transduction pathway; protein methylation; natural products; flavonoids; saponins; innate immunity; gastritis; colitis; hepatitis, arthritis, atopic dermatitis
Dr. Hassan Hosseinzadeh
E-Mail Website
Guest Editor
School of Health and Society, Faculty of the Arts, Social Sciences and Humanities, University of Wollongong, Wollongong, NSW 2522, Australia
Interests: chronic diseases; digital health; primary care and health promotion
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

It has been well documented that natural components could play critical roles in modern anti-inflammatory drug development. Inflammatory substances are usually divided into two main categories: pro- and anti-inflammatory mediators. Nevertheless, some mediators such as interleukin (IL)-12 possess both pro and anti-inflammatory properties. Among the inflammatory mediators and cellular pathways that have been extensively studied in association with human pathological conditions are cytokines , chemokines, eicosanoids and the potent inflammation-modulating transcription factor nuclear factor κ B. Natural components have been reported to exert anti-inflammatory activity both in vitro and in vivo conditions, and they have an impact on the pro-inflammatory gene expression, such as cyclooxygenase-2, nitric oxide synthase, pivotal cytokine etc. In this Special Issue, we will discuss the natural components, their roles in inflammation, and the therapeutic potential of these agents. The papers published here will surely contribute to proposing new additional insights into the anti-inflammatory mechanism of natural components. Importantly, the exact active ingredient of plant extract must be reported in the submitted research manuscript, since papers describing effects of mixed extraction from plants will not be accepted.

Prof. Dr. Jae Cho
Dr. Hassan Hosseinzadeh
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

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Keywords

  • Acute inflammation
  • Chronic inflammation
  • Macrophages
  • Signal transduction
  • Protein kinases
  • Pro-inflammatory cytokines

Published Papers (2 papers)

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Research

Article
Isoleucilactucin Ameliorates Coal Fly Ash-Induced Inflammation through the NF-κB and MAPK Pathways in MH-S Cells
Int. J. Mol. Sci. 2021, 22(17), 9506; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22179506 - 01 Sep 2021
Viewed by 806
Abstract
We investigated whether isoleucilactucin, an active constituent of Ixeridium dentatum, reduces inflammation caused by coal fly ash (CFA) in alveolar macrophages (MH-S). The anti-inflammatory effects of isoleucilactucin were assessed by measuring the concentration of nitric oxide (NO) and the expression of pro-inflammatory [...] Read more.
We investigated whether isoleucilactucin, an active constituent of Ixeridium dentatum, reduces inflammation caused by coal fly ash (CFA) in alveolar macrophages (MH-S). The anti-inflammatory effects of isoleucilactucin were assessed by measuring the concentration of nitric oxide (NO) and the expression of pro-inflammatory mediators in MH-S cells exposed to CFA-induced inflammation. We found that isoleucilactucin reduced CFA-induced NO generation dose-dependently in MH-S cells. Moreover, isoleucilactucin suppressed CFA-activated proinflammatory mediators, including cyclooxygenase-2 (COX2) and inducible NO synthase (iNOS), and the proinflammatory cytokines such as interleukin-(IL)-1β, IL-6, and tumor necrosis factor (TNF-α). The inhibiting properties of isoleucilactucin on the nuclear translocation of phosphorylated nuclear factor-kappa B (p-NF-κB) were observed. The effects of isoleucilactucin on the NF-κB and mitogen-activated protein kinase (MAPK) pathways were also measured in CFA-stimulated MH-S cells. These results indicate that isoleucilactucin suppressed CFA-stimulated inflammation in MH-S cells by inhibiting the NF-κB and MAPK pathways, which suggest it might exert anti-inflammatory properties in the lung. Full article
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Article
Mechanisms and Effect of Coptidis Rhizoma on Obesity-Induced Inflammation: In Silico and In Vivo Approaches
Int. J. Mol. Sci. 2021, 22(15), 8075; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22158075 - 28 Jul 2021
Viewed by 546
Abstract
Obesity is characterized as a chronic, low-grade inflammation state accompanied by the infiltration of immune cells into adipose tissue and higher levels of inflammatory cytokines and chemokines. This study aimed to investigate the mechanisms and effects of Coptidis Rhizoma (CR) on obesity and [...] Read more.
Obesity is characterized as a chronic, low-grade inflammation state accompanied by the infiltration of immune cells into adipose tissue and higher levels of inflammatory cytokines and chemokines. This study aimed to investigate the mechanisms and effects of Coptidis Rhizoma (CR) on obesity and its associated inflammation. First, we applied a network pharmacology strategy to search the target genes and pathways regulated by CR in obesity. Next, we performed in vivo experiments to confirm the antiobesity and anti-inflammatory effects of CR. Mice were assigned to five groups: normal chow (NC), control (high-fat diet (HFD)), HFD + CR 200 mg/kg, HFD + CR 400 mg/kg, and HFD + metformin 200 mg/kg. After 16 weeks of the experimental period, CR administration significantly reduced the weight of the body, epididymal fat, and liver; it also decreased insulin resistance, as well as the area under the curve of glucose in the oral glucose tolerance test and triglyceride in the oral fat tolerance test. We observed a decrease in adipose tissue macrophages (ATMs) and inflammatory M1 ATMs, as well as an increase in anti-inflammatory M2 ATMs. Gene expression levels of inflammatory cytokines and chemokines, including tumor necrosis factor-α, F4/80, and C-C motif chemokine (CCL)-2, CCL4, and CCL5, were suppressed in adipose tissue in the CR groups than levels in the control group. Additionally, histological analyses suggested decreased fat accumulation in the epididymal fat pad and liver in the CR groups than that in the control group. Taken together, these results suggest that CR has a therapeutic effect on obesity-induced inflammation, and it functions through the inhibition of macrophage-mediated inflammation in adipose tissue. Full article
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