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Special Issue "Molecular Biology of Parathyroid Tumors 2.0"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".

Deadline for manuscript submissions: 31 March 2022.

Special Issue Editor

Prof. Dr. Sabrina Corbetta
E-Mail Website
Guest Editor
Endocrinology and Diabetology Service, Department of Biomedical, Surgical and Dental Sciences, University of Milan, IRCCS Istituto Ortopedico Galeazzi, Milan, Italy
Interests: primary hyperparathyroidism; Calcium-sensing receptor; parathyroid tumors; microRNAs; MEN1; osteoporosis
Special Issues and Collections in MDPI journals

Special Issue Information

Dear Colleagues,

Parathyroid tumors are the second most common endocrine neoplasia. They are mainly benign lesions associated with parathormone (PTH) inappropriate secretion, determining the metabolic disorder known as primary hyperparathyroidism (PHPT). Parathyroid tumors are characterized by calcium-sensing receptor (CASR)-mediated reduced sensitivity to extracellular calcium. Genetic and epigenetic alterations resulting in aberrant expression of protein-coding and non-coding genes have been identified in parathyroid tumors. Besides inactivating mutations of the oncosuppressors MEN1 and HRPT2/CDC73, epigenetic changes have been reported. Impaired DNA methylation involving single genes, the deregulated expression of microRNAs, and long noncoding RNAs have started to be to be investigated. However, many aspects of the molecular biology of the parathyroid tumors need to be explored, such as the molecular pathways related to the genetic and epigenetic aberrations, and their effects on parathyroid cell proliferation and/or sensitivity to extracellular calcium, in order to provide targets for new therapeutic approaches, which are lacking.

The Special Issue aims to widely explore the molecular and biological features of parathyroid tumorigenesis, focusing on genetic and epigenetic aspects, parathyroid cell proliferation and biology, tumor microenvironment, CASR-mediated sensitivity to extracellular calcium, deregulation of the PTH release, and the differences between the benign and malignant behavior of the parathyroid cells, considering original articles and review papers.

Prof. Dr. Sabrina Corbetta
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Parathyroi adenomas
  • Parathyroid cancers
  • MEN1
  • CDC73
  • Calcium sensing receptor (CASR)
  • microRNAs
  • methylation
  • LncRNAs
  • Epigenetics
  • PTH
  • Parathyroid cell proliferation

Published Papers

This special issue is now open for submission, see below for planned papers.

Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Dear Colleagues,

Parathyroid tumors are the second most common endocrine neoplasia. They are mainly benign lesions associated with parathormone (PTH) inappropriate secretion, determining the metabolic disorder known as primary hyperparathyroidism (PHPT). Parathyroid tumors are characterized by calcium-sensing receptor (CASR)-mediated reduced sensitivity to extracellular calcium. Genetic and epigenetic alterations resulting in aberrant expression of protein-coding and non-coding genes have been identified in parathyroid tumors. Besides inactivating mutations of the oncosuppressors MEN1 and HRPT2/CDC73, epigenetic changes have been reported. Impaired DNA methylation involving single genes, the deregulated expression of microRNAs, and long noncoding RNAs have started to be to be investigated. However, many aspects of the molecular biology of the parathyroid tumors need to be explored, such as the molecular pathways related to the genetic and epigenetic aberrations, and their effects on parathyroid cell proliferation and/or sensitivity to extracellular calcium, in order to provide targets for new therapeutic approaches, which are lacking.

The Special Issue aims to widely explore the molecular and biological features of parathyroid tumorigenesis, focusing on genetic and epigenetic aspects, parathyroid cell proliferation and biology, tumor microenvironment, CASR-mediated sensitivity to extracellular calcium, deregulation of the PTH release, and the differences between the benign and malignant behavior of the parathyroid cells, considering original articles and review papers.

Prof. Dr. Sabrina Corbetta
Guest Editor

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