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Special Issue "Colorectal Cancer and Adjacent Normal Mucosa Differ in Apoptotic and Inflammatory Protein Expression"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".

Deadline for manuscript submissions: closed (31 August 2021).

Special Issue Editor

Dr. Paola Sena
E-Mail Website
Guest Editor
Surgical, Medical, Dental, and Morphological Sciences Department with an Interest in Transplant, Oncology and Regenerative Medicine, University of Modena and Reggio Emilia, Policlinico, Via Del Pozzo 71, I-41125 Modena, Italy
Interests: colorectal cancer; apoptosis; inflammation; ovarian cancer; hormonal disorders

Special Issue Information

Dear Colleagues,

Today, colorectal cancer is the fourth most common type of tumor all over the world. CRC is the result of interactions between environmental and genetic factors. Among the former, the presence of chronic inflammation (as in inflammatory bowel diseases) is considered particularly important. As far as carcinogenesis is concerned, it is widely accepted that tumorigenesis results from an imbalance between cell proliferation and cell death. It is also becoming clearer that in response to cellular stresses, cells may use multiple mechanisms that ultimately determine cell death or survival. The molecular mechanisms underlying the disturbances, hereditary or acquired, of the function of the immune system and of the apoptotic pathways that regulate protection, promotion or tolerance against neoplastic transformation are still debated. Moreover, the colorectal adenoma–carcinoma sequence has provided a paradigmatic framework for understanding successive somatic genetic changes and consequent clonal expansions that lead to cancer. However, an understanding of the earliest phases of colorectal neoplastic changes—which may occur in morphologically normal tissue—is comparatively limited, as for most cancer types.

Dr. Paola Sena
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Molecular changes 
  • Colorectal cancer 
  • Normal mucosa 
  • Apoptotic proteins 
  • Inflammatory mechanism 
  • Adenoma–carcinoma sequence 
  • Early diagnosis

Published Papers

There is no accepted submissions to this special issue at this moment.
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