Special Issue "Colorectal Cancer and Adjacent Normal Mucosa Differ in Apoptotic and Inflammatory Protein Expression"
Deadline for manuscript submissions: closed (31 August 2021).
Interests: colorectal cancer; apoptosis; inflammation; ovarian cancer; hormonal disorders
Today, colorectal cancer is the fourth most common type of tumor all over the world. CRC is the result of interactions between environmental and genetic factors. Among the former, the presence of chronic inflammation (as in inflammatory bowel diseases) is considered particularly important. As far as carcinogenesis is concerned, it is widely accepted that tumorigenesis results from an imbalance between cell proliferation and cell death. It is also becoming clearer that in response to cellular stresses, cells may use multiple mechanisms that ultimately determine cell death or survival. The molecular mechanisms underlying the disturbances, hereditary or acquired, of the function of the immune system and of the apoptotic pathways that regulate protection, promotion or tolerance against neoplastic transformation are still debated. Moreover, the colorectal adenoma–carcinoma sequence has provided a paradigmatic framework for understanding successive somatic genetic changes and consequent clonal expansions that lead to cancer. However, an understanding of the earliest phases of colorectal neoplastic changes—which may occur in morphologically normal tissue—is comparatively limited, as for most cancer types.
Dr. Paola Sena
Manuscript Submission Information
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- Molecular changes
- Colorectal cancer
- Normal mucosa
- Apoptotic proteins
- Inflammatory mechanism
- Adenoma–carcinoma sequence
- Early diagnosis