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Special Issue "Fatty Acids and Inflammation: From Biochemistry to Human Evidence"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: 31 October 2021.

Special Issue Editors

Prof. Dr. Carlo Agostoni
E-Mail Website1 Website2
Guest Editor
Department of Clinical Sciences and Community Health (DISCCO), University of Milan, 20122 Milan, Italy
Interests: n-3 polyunsaturated fatty acids; nutrition; lipid metabolism; metabolic diseases; EPA; DHA; neurodevelopment
Special Issues and Collections in MDPI journals
Prof. Dr. Francesco Visioli
E-Mail Website
Guest Editor
Department of Molecular Medicine, Università degli Studi di Padova, Padua, Italy
Interests: micronutrients; fatty acids; (poly)phenols; vitamins; pharma-nutrition; neurodegeneration; milk components

Special Issue Information

Dear Colleagues,

Inflammation, especially that which is low-grade and chronic, triggers downstream processes that play crucial roles in the development of degenerative diseases such as atherosclerosis, cancer, and neurodegeneration. Furthermore, joint health and gastrointestinal wellbeing are largely modulated by inflammatory status. The individual status may easily switch from positive to negative depending on either genetic or environmental variables, respectively. Unlike genetic variables, environmental determinants may be changed in order to orient the individual inflammatory status towards a more favorable balance.

Among the environmental determinants, diet and many of its components may modulate inflammation via enzyme inhibition, substrate availability for the formation of inflammatory mediators, and active resolution of inflammation. In this respect, fatty acids are of paramount importance because of their ability to alter membranes’ composition, inhibit the inflammatory cascade, and form molecules that actively participate in inflammation’s resolution.

We aim to collate important contributions that will form a state-of-the-art Special Issue useful to basic researchers and practitioners alike, with the overarching goal of moving the field further.


Prof. Dr. Carlo Agostoni
Prof. Dr. Francesco Visioli
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • arachidonic acid
  • eicosapentaenoic acid
  • docosahexaenoic acid
  • eicosanoids
  • prostaglandins
  • cytokines
  • inflammation

Published Papers (1 paper)

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Effects of Dietary n–3 and n–6 Polyunsaturated Fatty Acids in Inflammation and Cancerogenesis
Int. J. Mol. Sci. 2021, 22(13), 6965; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22136965 - 28 Jun 2021
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The dietary recommendation encourages reducing saturated fatty acids (SFA) in diet and replacing them with polyunsaturated fatty acids (PUFAs) n–3 (omega–3) and n–6 (omega–6) to decrease the risk of metabolic disturbances. Consequently, excessive n–6 PUFAs content and high n–6/n–3 ratio are found in [...] Read more.
The dietary recommendation encourages reducing saturated fatty acids (SFA) in diet and replacing them with polyunsaturated fatty acids (PUFAs) n–3 (omega–3) and n–6 (omega–6) to decrease the risk of metabolic disturbances. Consequently, excessive n–6 PUFAs content and high n–6/n–3 ratio are found in Western-type diet. The importance of a dietary n–6/n–3 ratio to prevent chronic diseases is linked with anti-inflammatory functions of linolenic acid (ALA, 18:3n–3) and longer-chain n–3 PUFAs. Thus, this review provides an overview of the role of oxylipins derived from n–3 PUFAs and oxylipins formed from n–6 PUFAs on inflammation. Evidence of PUFAs’ role in carcinogenesis was also discussed. In vitro studies, animal cancer models and epidemiological studies demonstrate that these two PUFA groups have different effects on the cell growth, proliferation and progression of neoplastic lesions. Full article
(This article belongs to the Special Issue Fatty Acids and Inflammation: From Biochemistry to Human Evidence)
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