Special Issue "Glucocorticoids and Metabolic Disorders"
Deadline for manuscript submissions: 30 June 2021.
Glucocorticoids, besides having well-known anti-inflammatory and immunosuppressive effects, also play a significant role in the control of metabolism and energy homeostasis.
Their production by the adrenal cortex under control of the hypothalamic–pituitary–adrenal axis occurs in parallel to the tissue-specific (e.g., liver and adipose tissue) mediated modulation of active glucocorticoid levels. The endoplasmic reticulum enzymes 11b-hydroxysteroid dehydrogenase types 1 and 2 regulate the active cortisol concentration at the pre-receptorial level, thus allowing fine-tuning of the glucocorticoid action in specific anatomic locations. These steroid hormones control the physiological equilibrium of metabolic functions, and an imbalance in the glucocorticoid–glucocorticoid receptor signaling can easily lead to severe alterations of proper metabolic control, affecting carbohydrate, protein and lipid metabolism. Metabolic disturbances involving glucocorticoids have been described in hyperglycemia, insulin resistance, diabetes, dyslipidemia, obesity and hypertension, all of which are risk factors for cardiovascular diseases; indeed, these clustered conditions define the metabolic syndrome.
This Special Issue “Glucocorticoids and Metabolic Disorders” calls for research papers and review articles focusing on different aspects of the connection between glucocorticoids and metabolism in order to provide a clear and up-to-date picture of the role of these steroid hormones in the pathogenesis of metabolic disturbances.
Dr. Paola Marcolongo
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
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- Metabolic disorders
- 11β-hydroxysteroid dehydrogenase 1(11β-HSD1)
- Endoplasmic reticulum
- Insulin resistance
- Cardiovascular diseases
- Metabolic syndrome