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Special Issue "Glucocorticoids and Metabolic Disorders"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: 30 June 2021.

Special Issue Editor

Dr. Paola Marcolongo
E-Mail Website
Guest Editor
Molecular and Developmental Medicine Dept., University of Siena, Siena, Italy
Interests: Glycogen storage disease type 1b; Endoplasmic reticulum enzymes; glucocorticoids; Arterial Tortuosity Syndrome; autophagy; nutrients and hypertension

Special Issue Information

Dear colleagues,

Glucocorticoids, besides having well-known anti-inflammatory and immunosuppressive effects, also play a significant role in the control of metabolism and energy homeostasis.

Their production by the adrenal cortex under control of the hypothalamic–pituitary–adrenal axis occurs in parallel to the tissue-specific (e.g., liver and adipose tissue) mediated modulation of active glucocorticoid levels. The endoplasmic reticulum enzymes 11b-hydroxysteroid dehydrogenase types 1 and 2 regulate the active cortisol concentration at the pre-receptorial level, thus allowing fine-tuning of the glucocorticoid action in specific anatomic locations. These steroid hormones control the physiological equilibrium of metabolic functions, and an imbalance in the glucocorticoid–glucocorticoid receptor signaling can easily lead to severe alterations of proper metabolic control, affecting carbohydrate, protein and lipid metabolism. Metabolic disturbances involving glucocorticoids have been described in hyperglycemia, insulin resistance, diabetes, dyslipidemia, obesity and hypertension, all of which are risk factors for cardiovascular diseases; indeed, these clustered conditions define the metabolic syndrome.

This Special Issue “Glucocorticoids and Metabolic Disorders” calls for research papers and review articles focusing on different aspects of the connection between glucocorticoids and metabolism in order to provide a clear and up-to-date picture of the role of these steroid hormones in the pathogenesis of metabolic disturbances.

Dr. Paola Marcolongo
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Glucocorticoids
  • Metabolic disorders
  • 11β-hydroxysteroid dehydrogenase 1(11β-HSD1)
  • Endoplasmic reticulum
  • Obesity
  • Insulin resistance
  • Cardiovascular diseases
  • Metabolic syndrome

Published Papers

This special issue is now open for submission.
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