Special Issue "Molecular Research on Huntington’s Disease"
Deadline for manuscript submissions: 31 October 2021.
Interests: Huntington’s disease; trinucleotide expansions; epigenetics; transcription
Interests: Huntington's Disease
Huntington’s disease (HD) is a fatal neurodegenerative disorder caused by an aberrant expansion of CAG repeats at the HTT exon 1 locus, which mainly affects the basal ganglia in patients. Despite knowing the cause of the disease, an effective cure is still elusive. However, extensive research has been conducted in the recent years to elucidate the etiopathogenic mechanisms that are triggered as a consequence of the production of an mHTT polyglutamine peptide and the loss of a functional allele, which in combination, alter multiple cellular processes (e.g., transcription and epigenetics, mitochondrial respiration, proteasomal degradation, vesicle trafficking, neurotransmitter release, etc.) that cumulatively compromise cell viability and the survival. Although neurons are specially affected, the functionality of other cell types can also be relevant in the disease. In this Special Issue, we intend to provide an updated overview of the most prominent molecular events that are behind the complex symptomatology in HD patients, by including original research and reviews that describe molecular mechanisms that have been modelled in cellular preparations and genetically modified animals with a clear potential to be translated into the clinics by proposing biomarkers of prognosis aimed at improving clinical counselling and disease monitoring and/or therapeutical approaches for amelioration of the disease in patients.
Dr. Luis M. Valor
Dr. Antonio Campos-Caro
Manuscript Submission Information
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- Huntington’s disease
- molecular mechanisms
- therapeutical targets
- preclinical and translational studies