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Special Issue "Molecular Research on Huntington’s Disease"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".

Deadline for manuscript submissions: 31 October 2021.

Special Issue Editors

Dr. Luis M. Valor
E-Mail Website
Guest Editor
Instituto de Investigación e Innovación en Ciencias Biomédicas de la Provincia de Cádiz (INiBICA), Cádiz, Spain
Interests: Huntington’s disease; trinucleotide expansions; epigenetics; transcription
Dr. Antonio Campos-Caro
E-Mail
Guest Editor
Instituto de Investigación e Innovación en Ciencias Biomédicas de la Provincia de Cádiz (INiBICA), Cádiz, Spain
Interests: Huntington's Disease

Special Issue Information

Dear Colleagues,

Huntington’s disease (HD) is a fatal neurodegenerative disorder caused by an aberrant expansion of CAG repeats at the HTT exon 1 locus, which mainly affects the basal ganglia in patients. Despite knowing the cause of the disease, an effective cure is still elusive. However, extensive research has been conducted in the recent years to elucidate the etiopathogenic mechanisms that are triggered as a consequence of the production of an mHTT polyglutamine peptide and the loss of a functional allele, which in combination, alter multiple cellular processes (e.g., transcription and epigenetics, mitochondrial respiration, proteasomal degradation, vesicle trafficking, neurotransmitter release, etc.) that cumulatively compromise cell viability and the survival. Although neurons are specially affected, the functionality of other cell types can also be relevant in the disease. In this Special Issue, we intend to provide an updated overview of the most prominent molecular events that are behind the complex symptomatology in HD patients, by including original research and reviews that describe molecular mechanisms that have been modelled in cellular preparations and genetically modified animals with a clear potential to be translated into the clinics by proposing biomarkers of prognosis aimed at improving clinical counselling and disease monitoring and/or therapeutical approaches for amelioration of the disease in patients.

Dr. Luis M. Valor
Dr. Antonio Campos-Caro
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Huntington’s disease
  • molecular mechanisms
  • biomarkers
  • therapeutical targets
  • preclinical and translational studies
  • patients

Published Papers

This special issue is now open for submission.
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