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Special Issue "The Role of the IGF Axis in Cancer"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".

Deadline for manuscript submissions: 31 December 2021.

Special Issue Editor

Dr. Claire M Perks
E-Mail Website
Guest Editor
Insulin-like Growth Factors and Metabolic Endocrinology Group, Bristol Medical School, Southmead Hospital, Bristol, UK
Interests: metabolic disturbances; IGFs and epithelial cancers
Special Issues and Collections in MDPI journals

Special Issue Information

Dear Colleagues, 

This Special Issue is the continuation of our previous special issue "The Role of the IGF Axis in the Disease".

This research topic aims to highlight the key roles that members of the IGF axis (ligands, IGFBPs, and receptors) play in the risk and progression of cancer and how these roles are often exacerbated by disturbed metabolic status. It will encompass their roles in cancer risk and how they utilise the hallmarks of cancer, such as angiogenesis, proliferation, metabolism and survival, to drive tumour development and potential approaches to target this axis.

Dr. Claire M Perks
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • IGF axis
  • cancer
  • obesity
  • hallmarks of cancer

Published Papers (1 paper)

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Review

Review
The Roles of the IGF Axis in the Regulation of the Metabolism: Interaction and Difference between Insulin Receptor Signaling and IGF-I Receptor Signaling
Int. J. Mol. Sci. 2021, 22(13), 6817; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22136817 - 24 Jun 2021
Cited by 1 | Viewed by 701
Abstract
It has been well established that insulin-like growth factors (IGFs) mainly mediate long-term actions in cell fates, whereas insulin predominantly exerts its role on metabolic activity. Indeed, insulin mediates multiple anabolic biological activities in glucose and amino acid transport, lipid and protein synthesis, [...] Read more.
It has been well established that insulin-like growth factors (IGFs) mainly mediate long-term actions in cell fates, whereas insulin predominantly exerts its role on metabolic activity. Indeed, insulin mediates multiple anabolic biological activities in glucose and amino acid transport, lipid and protein synthesis, the induction of glycogen, the inhibition of gluconeogenesis, lipolysis, and protein degradation. The interactions and differences between insulin receptor signaling and IGF-I receptor signaling in the metabolism and the cell fates are quite complicated. Because of the overlapping actions of IGF-I singling with insulin signaling, it has been difficult to distinguish the role of both signaling mechanisms on the metabolism. Furthermore, comprehensive information on the IGF-I function in respective tissues remains insufficient. Therefore, we need to clarify the precise roles of IGF-I signaling on the metabolism separate from those of insulin signaling. This review focuses on the metabolic roles of IGFs in the respective tissues, especially in terms of comparison with those of insulin, by overviewing the metabolic phenotypes of tissue-specific IGF-I and insulin receptor knockout mice, as well as those in mice treated with the dual insulin receptor/IGF-I receptor inhibitor OSI-906. Full article
(This article belongs to the Special Issue The Role of the IGF Axis in Cancer)
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