Special Issue "Mitochondrial DNA and RNA"
Deadline for manuscript submissions: 31 October 2021.
Mitochondria are the primary sites of ATP production and are also involved in several other important cellular processes such as programmed cell death and cell signaling. Mitochondria are surrounded by a double-membrane system consisting of inner and outer mitochondrial membranes separated by an intermembrane space. The inner membrane delimitates the innermost compartment, the matrix, where mitochondrial DNA (mtDNA) resides. Human mtDNA is circular, 16 kbp long molecule that encodes 13 proteins, two ribosomal RNAs, and 22 tRNAs. Once transcribed, mitochondrial RNA (mtRNA) is processed, mitoribosomes are assembled, and mtDNA-encoded proteins belonging to the respiratory chain are synthesized. All these processes require the coordinated spatiotemporal action of several enzymes, and many different factors are involved in the regulation and control of protein synthesis and in the stability and turnover of mitochondrial DNA and RNA.
The goal of this Special Issue is to present the current knowledge on mtDNA replication and repair mechanisms, processing of mitochondrial RNA transcripts, and how alteration of these processes may affect cell physiology in pathological conditions.
The formats for submissions include original research reports, reviews, perspectives/opinions, and methodology articles.
Dr. Carlo Vascotto
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- DNA repair and replication
- RNA processing
- mitochondrial transcription