International Journal of Molecular Sciences

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Special Issue Editors

Dr. Julien Dairou

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Collection Editor

Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologique, Université de Paris, UMR 8601, CNRS, F-75013 Paris, France
Interests: glycation; Park7; enzymology; toxicology; analytical chemistry; oxidative stress; xenobiotic; metabolism
Special Issues, Collections and Topics in MDPI journals

Prof. Dr. Xavier Coumoul

E-Mail Website
Collection Editor

Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologique, Université de Paris, UMR 8601, CNRS, F-75013 Paris, France
Interests: toxicology; environmental pollutants; AhR signaling pathway; xenobiotic; metabolism

Special Issue Information

Dear Colleagues,

This Topical Collection aims to provide a comprehensive overview of state-of-the-art of Molecular Toxicology in France. We invite research papers that will consolidate our understanding in this area. The Topical Collection will publish full research articles and comprehensive reviews. Potential topics include but are not limited to the following research areas:

Food, drugs and chemical toxicology
Genetic toxicology
Reproductive toxicology
Neurotoxicology
Nanotoxicology
Environmental toxicology and ecotoxicology
Computational and predictive toxicology
Food–drug interactions
Idiosyncratic toxicity
Toxins

Dr. Julien Dairou
Prof. Dr. Xavier Coumoul
Collection Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

food, drugs and chemical toxicology
genetic toxicology
reproductive toxicology
neurotoxicology
nanotoxicology
environmental toxicology and ecotoxicology
computational and predictive toxicology
food–drug interactions
idiosyncratic toxicity
toxins

Published Papers (2 papers)

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Research

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14 pages, 2375 KiB

Open AccessArticle

About the Transient Effects of Synthetic Amorphous Silica: An In Vitro Study on Macrophages

by Anaëlle Torres, Véronique Collin-Faure, Daphna Fenel, Jacques-Aurélien Sergent and Thierry Rabilloud

Int. J. Mol. Sci. 2023, 24(1), 220; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms24010220 - 22 Dec 2022

Viewed by 1477

Abstract

Silica (either crystalline or amorphous) is widely used for different applications and its toxicological assessment depends on its characteristics and intended use. As sustained inflammation induced by crystalline silica is at the root of silicosis, investigating the inflammatory effects induced by amorphous silicas and their persistence is needed. For the development of new grades of synthetic amorphous silicas, it is also desirable to be able to understand better the factors underlying potential adverse effects. Therefore, we used an optimized in vitro macrophage system to investigate the effects of amorphous silicas, and their persistence. By using different amorphous silicas, we demonstrated that the main driver for the adverse effects is a low size of the overall particle/agglomerate; the second driver being a low size of the primary particle. We also demonstrated that the effects were transient. By using silicon dosage in cells, we showed that the transient effects are coupled with a decrease of intracellular silicon levels over time after exposure. To further investigate this phenomenon, a mild enzymatic cell lysis allowed us to show that amorphous silicas are degraded in macrophages over time, explaining the decrease in silicon content and thus the transiency of the effects of amorphous silicas on macrophages. Full article

(This article belongs to the Special Issue State-of-the-Art Molecular Toxicology in France)

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Review

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26 pages, 1225 KiB

Open AccessReview

Studying the Impact of Persistent Organic Pollutants Exposure on Human Health by Proteomic Analysis: A Systematic Review

by Sophie Guillotin and Nicolas Delcourt

Int. J. Mol. Sci. 2022, 23(22), 14271; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms232214271 - 17 Nov 2022

Cited by 6 | Viewed by 2181

Abstract

Persistent organic pollutants (POPs) are organic chemical substances that are widely distributed in environments around the globe. POPs accumulate in living organisms and are found at high concentrations in the food chain. Humans are thus continuously exposed to these chemical substances, in which they exert hepatic, reproductive, developmental, behavioral, neurologic, endocrine, cardiovascular, and immunologic adverse health effects. However, considerable information is unknown regarding the mechanism by which POPs exert their adverse effects in humans, as well as the molecular and cellular responses involved. Data are notably lacking concerning the consequences of acute and chronic POP exposure on changes in gene expression, protein profile, and metabolic pathways. We conducted a systematic review to provide a synthesis of knowledge of POPs arising from proteomics-based research. The data source used for this review was PubMed. This study was carried out following the PRISMA guidelines. Of the 742 items originally identified, 89 were considered in the review. This review presents a comprehensive overview of the most recent research and available solutions to explore proteomics datasets to identify new features relevant to human health. Future perspectives in proteomics studies are discussed. Full article

(This article belongs to the Special Issue State-of-the-Art Molecular Toxicology in France)

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