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Special Issue "The Role of Natural Compounds in Osteoblastic and Osteoclastic Cells"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".

Deadline for manuscript submissions: 31 August 2021.

Special Issue Editors

Dr. Seon-Yong Jeong
Guest Editor
Dr. Eunkuk Park
Co-Guest Editor
Department of Medical Genetics, Ajou University School of Medicine, Suwon, Republic of Korea.
Interests: osteoporosis; osteoarthritis; obesity; woman's menopause; cognitive impairment; phytomedicine; natural compounds; animal study

Special Issue Information

Dear Colleagues,

Osteoporosis is an abnormal bone remodeling condition characterized by decreased bone density, which leads to high risks of fracture. It is a common disease caused by an imbalance between bone resorption by osteoclasts and bone formation by osteoblasts. Osteoporosis is a major concern in public health care, and causes severe consequences if left untreated. Although a few potent pharmacological therapies are available for the treatment of osteoporosis, most of these drugs have side effects. Herbal treatment for osteoporosis would be advantageous because natural plants have fewer side effects, making them more suitable for long‐term use. The preventive and therapeutic effects of phytochemicals, as potential alternative treatments for osteoporosis, have been reported.

We are particularly interested in manuscripts that describe the role of natural compounds in the bone remodeling process through the induction of osteoblast differentiation and/or the reduction of osteoclast differentiation. Therefore, this Special Issue will focus on the mode of action (molecular mechanisms) underlying the anti-osteoporotic effects of natural compounds. Original research articles, reviews, and letters on these topics are welcome in this Special Issue. It is also necessary to clarify the exact functional ingredient in the submitted research papers. We will not accept papers on mixed extraction.

Dr. Seon-Yong Jeong

Dr. Eunkuk Park
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • osteoporosis
  • fracture
  • herbal medicine
  • phytotherapy
  • natural compounds
  • molecular mechanism
  • bone remodeling
  • bone formation
  • bone resorption
  • osteoblasts
  • osteoclasts

Published Papers

This special issue is now open for submission.
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