Special Issue "Osteogenic and Chondrogenic Differentiation of Mesenchymal Stem Cells"
Deadline for manuscript submissions: 28 February 2022.
Interests: cell biology; stem cells; differentiation; osteogenesis; chondrogenesis; biophysical stimulation; pulsed electromagnetic field; differentiation ability; signaling
The concept of stem cells originated at the end of the 19th century because of the ability of certain tissues (blood, skin, etc.) to self-renew during their lifetime. Several years later, these cells were identified and isolated. Since then, methods for mesenchymal stem cell (MSC) isolation, characterization, expansion in culture and evaluation of differentiation abilities have been impressively investigated. In the last 5 years alone, more than 33,102 papers have reported information on MSCs. MSCs have a crucial role in skeletal tissue regeneration. Due to their osteogenic and chondrogenic potential, they have acquired a prominent role in tissue engineering and regenerative medicine for bone and cartilage tissues. Most studies remain focused on bone marrow MSCs (BMSCs), although it is now known that MSCs are present in several other adult tissues. In spite of the growing knowledge, several questions still remain open: the identification of the optimal cellular source, the molecular basis for MSC population heterogeneity among tissue sources, parts of the body, as well as different donors and cell phenotypes, the optimization of the expansion and differentiation protocols to achieve stable osteogenic and chondrogenic phenotypes, and the impact of senescence. In addition, signaling pathways, epigenetic regulation and cell-to-cell communications still need to be clarified. We welcome submissions, including original papers and reviews, on these open questions. It is expected that these findings may help to favor skeletal tissue repair and optimize MSC use to efficiently manage joint disease.
Prof. Dr. Monica de Mattei
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
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- stem cells
- markers of differentiation
- epigenetic regulation
- stem cell heterogeneity
- stem cell senescence