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Precision Medicine and New Trends of Molecular Sciences in Vascular Disease

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: closed (31 October 2023) | Viewed by 3512

Special Issue Editors


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Guest Editor
Department of Public Health, Vascular Surgery Unit, University Federico II of Naples, 80138 Naples, Italy
Interests: peripheral artery disease; abdominal aortic aneurysm; carotid artery disease

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Guest Editor
Department of Health Sciences, Magna Graecia University of Catanzaro, 88100 Catanzaro, Italy
Interests: renal failure; Anderson Fabry disease; vasculopaties
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Vascular disease (VD) is the leading cause of morbidity and mortality worldwide. VD encompasses the consequences of localized atherosclerosis such as peripheral artery disease (PAD) and carotid artery stenosis (CAS); aneurysmal degeneration such as aortic aneurysm (AA); vein diseases such as chronic venous disease (CVD) and venous thromboembolism (VTE); and vascular wounds such as diabetic foot ulcer (DFU), venous leg ulcer (VLU), and arterial leg ulcer (ALU). Several risk factors contribute to the onset of subclinical disease that may progress to overt disease. Primary prevention, secondary prevention, and tertiary prevention strategies for VD are public health priorities.

In the context of precision medicine (PM), novel biomarkers related to molecular sciences research and application may be used as screening and risk-assessment tools to identify patients who are vulnerable to VD. In fact, the recent experimental technical progress related to biology, chemistry, and molecular medicine has allowed scientists to find effective biomarkers to assess and identify high-risk individuals, to ensure prompt and accurate diagnosis, and to follow up on patients that have undergone medical treatment and/or vascular and endovascular surgery procedures.

Currently, the complex approach to illness considers biology and medicine connected to social and molecular determinants of health that are strictly related to molecular sciences and biomarkers.

For this Special Issue, we invite investigators to contribute with original research and review papers that provide new insights into the underlying mechanisms of VD as well as work on new diagnostic and prognostic tools/biomarkers related to therapeutic strategies (data on molecular mechanisms or pathophysiology are essential, and papers that only contain clinical trials/data are not acceptable).

The Guest Editor Prof. Dr. Raffaele Serra and co-Guest Editors Prof. Dr. Umberto Marcello Bracale and Prof. Dr. Michele Andreucci are supported for this Special Issue by Dr. Davide Costa, University of Catanzaro and Dr. Nicola Ielapi, Sapienza University of Rome.

Dr. Raffaele Serra
Prof. Dr. Umberto Marcello Bracale
Prof. Dr. Michele Andreucci
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • precision medicine
  • precision nursing
  • biomarkers
  • molecular biology
  • biochemistry
  • genetics
  • molecular sciences
  • molecular research
  • vascular disease
  • vascular surgery
  • wounds
  • diabetic foot ulcers
  • peripheral artery disease
  • chronic venous disease
  • abdominal aortic aneurysm
  • thoracic aortic aneurysm
  • peripheral aneurysm
  • social and molecular determinants of health

Published Papers (1 paper)

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Review

13 pages, 708 KiB  
Review
Molecular Determinants of Chronic Venous Disease: A Comprehensive Review
by Davide Costa, Michele Andreucci, Nicola Ielapi, Giuseppe Filiberto Serraino, Pasquale Mastroroberto, Umberto Marcello Bracale and Raffaele Serra
Int. J. Mol. Sci. 2023, 24(3), 1928; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms24031928 - 18 Jan 2023
Cited by 9 | Viewed by 3073
Abstract
Chronic Venous Disease (CVD) refers to several pathological and hemodynamic alterations of the veins of lower limbs causing a wide range of symptoms and signs with a high prevalence in the general population and with disabling consequences in the most severe forms. The [...] Read more.
Chronic Venous Disease (CVD) refers to several pathological and hemodynamic alterations of the veins of lower limbs causing a wide range of symptoms and signs with a high prevalence in the general population and with disabling consequences in the most severe forms. The etiology and pathophysiology of CVD is complex and multifactorial, involving genetic, proteomic, and cellular mechanisms that result in changes to the venous structure and functions. Expressions of several genes associated with angiogenesis, vascular development, and the regulation of veins are responsible for the susceptibility to CVD. Current evidence shows that several extracellular matrix alterations (ECM) could be identified and in some cases pharmacologically targeted. This review shows the most up to date information on molecular determinants of CVD in order to provide a complete overview of the current knowledge on this topic. In particular, the article explores the genetic influence, the hormonal influence, ECM imbalance, and histopathology of CVD and the role of endothelial dysfunction in CVD. Full article
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