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Cellular and Molecular Mechanisms of Bone Metastasis 2.0
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Cellular and Molecular Mechanisms of Bone Metastasis 2.0

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: closed (30 March 2020) | Viewed by 26153

Special Issue Editor

Prof. Dr. Maria Alfonsina Desiderio

E-Mail Website
Guest Editor
Department of Biomedical Sciences for Health, Molecular Pathology Laboratory, University of Milan, Milano, Italy
Interests: bone metastasis from breast carcinoma; hepatocyte growth factor; Met receptor; hypoxia; microenvironment; epithelial-mesenchymal transition; transcriptional regulation
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Skeleton metastases are the principal cause of death of patients with breast and prostate cancer, and multiple myeloma. Molecular medicine takes into consideration the molecular pathogenesis of bone metastasis to clarify the biology of the metastatic process, and to individuate targets for personalized therapy. Colonization of the skeleton by metastases is supported by genetic and epigenetic mechanisms, through systemic signals largely unknown, and local physical and biological stimuli of the microenvironment. Due to the multiple facets of the bone metastasic process, a multidisciplinary approach is strongly desirable to devise effective therapies. The bone metastatic process may be investigated from different points of view, including pathology, nanotechnology, and structural/biological engineering, as well as molecular biology. The principal topics of bone metastases, investigated with these methodologies, are the dysregulation of cellular events like autophagy, invasiveness, mesenchymal-epithelial transition and its reversion, and transcription factor networks.

This Special Issue, “Cellular and Molecular Mechanisms of Bone Metastasis”, will cover a selection of recent research topics and current review articles in the field of invasiveness and bone metastasis.

Prof. Dr. Maria Alfonsina Desiderio
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bone metastasis
  • breast carcinoma
  • prostate carcinoma
  • multiple myeloma
  • hypoxia
  • growth factors
  • epithelial-mesenchymal transition
  • epigenetic mechanisms
  • autophagy
  • Hippo pathway

Published Papers (3 papers)

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Review

25 pages, 1099 KiB  
Review
Switching Homes: How Cancer Moves to Bone
by Marco Ponzetti and Nadia Rucci
Int. J. Mol. Sci. 2020, 21(11), 4124; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21114124 - 09 Jun 2020
Cited by 14 | Viewed by 3754
Abstract
Bone metastases (BM) are a very common complication of the most prevalent human cancers. BM are extremely painful and may be life-threatening when associated with hypercalcaemia. BM can lead to kidney failure and cardiac arrhythmias and arrest, but why and how do cancer [...] Read more.
Bone metastases (BM) are a very common complication of the most prevalent human cancers. BM are extremely painful and may be life-threatening when associated with hypercalcaemia. BM can lead to kidney failure and cardiac arrhythmias and arrest, but why and how do cancer cells decide to “switch homes” and move to bone? In this review, we will present what answers science has provided so far, with focus on the molecular mechanisms and cellular aspects of well-established findings, such as the concept of “vicious cycle” and “osteolytic” vs. “osteosclerotic” bone metastases; as well as on novel concepts, such as cellular dormancy and extracellular vesicles. At the molecular level, we will focus on hypoxia-associated factors and angiogenesis, the Wnt pathway, parathyroid hormone-related peptide (PTHrP) and chemokines. At the supramolecular/cellular level, we will discuss tumour dormancy, id est the mechanisms through which a small contingent of tumour cells coming from the primary site may be kept dormant in the endosteal niche for many years. Finally, we will present a potential role for the multimolecular mediators known as extracellular vesicles in determining bone-tropism and establishing a premetastatic niche by influencing the bone microenvironment. Full article
(This article belongs to the Special Issue Cellular and Molecular Mechanisms of Bone Metastasis 2.0)
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29 pages, 886 KiB  
Review
microRNAs in the Antitumor Immune Response and in Bone Metastasis of Breast Cancer: From Biological Mechanisms to Therapeutics
by Marta Gomarasca, Paola Maroni, Giuseppe Banfi and Giovanni Lombardi
Int. J. Mol. Sci. 2020, 21(8), 2805; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21082805 - 17 Apr 2020
Cited by 16 | Viewed by 4348
Abstract
Breast cancer is the most common type of cancer in women, and the occurrence of metastasis drastically worsens the prognosis and reduces overall survival. Understanding the biological mechanisms that regulate the transformation of malignant cells, the consequent metastatic transformation, and the immune surveillance [...] Read more.
Breast cancer is the most common type of cancer in women, and the occurrence of metastasis drastically worsens the prognosis and reduces overall survival. Understanding the biological mechanisms that regulate the transformation of malignant cells, the consequent metastatic transformation, and the immune surveillance in the tumor progression would contribute to the development of more effective and targeted treatments. In this context, microRNAs (miRNAs) have proven to be key regulators of the tumor-immune cells crosstalk for the hijack of the immunosurveillance to promote tumor cells immune escape and cancer progression, as well as modulators of the metastasis formation process, ranging from the preparation of the metastatic site to the transformation into the migrating phenotype of tumor cells. In particular, their deregulated expression has been linked to the aberrant expression of oncogenes and tumor suppressor genes to promote tumorigenesis. This review aims at summarizing the role and functions of miRNAs involved in antitumor immune response and in the metastasis formation process in breast cancer. Additionally, miRNAs are promising targets for gene therapy as their modulation has the potential to support or inhibit specific mechanisms to negatively affect tumorigenesis. With this perspective, the most recent strategies developed for miRNA-based therapeutics are illustrated. Full article
(This article belongs to the Special Issue Cellular and Molecular Mechanisms of Bone Metastasis 2.0)
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Figure 1

20 pages, 2815 KiB  
Review
Bone Pain in Cancer Patients: Mechanisms and Current Treatment
by Renata Zajączkowska, Magdalena Kocot-Kępska, Wojciech Leppert and Jerzy Wordliczek
Int. J. Mol. Sci. 2019, 20(23), 6047; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms20236047 - 30 Nov 2019
Cited by 111 | Viewed by 17720
Abstract
The skeletal system is the third most common site for cancer metastases, surpassed only by the lungs and liver. Many tumors, especially those of the breast, prostate, lungs, and kidneys, have a strong predilection to metastasize to bone, which causes pain, hypercalcemia, pathological [...] Read more.
The skeletal system is the third most common site for cancer metastases, surpassed only by the lungs and liver. Many tumors, especially those of the breast, prostate, lungs, and kidneys, have a strong predilection to metastasize to bone, which causes pain, hypercalcemia, pathological skeletal fractures, compression of the spinal cord or other nervous structures, decreased mobility, and increased mortality. Metastatic cancer-induced bone pain (CIBP) is a type of chronic pain with unique and complex pathophysiology characterized by nociceptive and neuropathic components. Its treatment should be multimodal (pharmacological and non-pharmacological), including causal anticancer and symptomatic analgesic treatment to improve quality of life (QoL). The aim of this paper is to discuss the mechanisms involved in the occurrence and persistence of cancer-associated bone pain and to review the treatment methods recommended by experts in clinical practice. The final part of the paper reviews experimental therapeutic methods that are currently being studied and that may improve the efficacy of bone pain treatment in cancer patients in the future. Full article
(This article belongs to the Special Issue Cellular and Molecular Mechanisms of Bone Metastasis 2.0)
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