Special Issue "Calcium Handling"
Deadline for manuscript submissions: 30 September 2021.
Calcium ion (Ca2+) handling is the central coordinator of excitable cell functions. For neuronal, skeletal, cardiac or smooth muscle, and pancreatic beta cells, transient elevation of intracellular Ca2+ triggers molecular machines and produces key cellular responses, such as contraction and secretion. This is mediated through the maintenance of the resting cytosolic Ca2+ concentration, four orders of magnitude lower than the extracellular space and three orders of magnitude lower than the endoplasmic reticulum or the mitochondria. Upon excitation, these Ca2+ stores release Ca2+ to the cytosol through ion channels, while during relaxation, ATPase pumps reuptake cytosolic Ca2+ to its stores. These channels and pumps are under the control of accessory proteins that modify their function upon extracellular or intracellular signaling. Genetic variations, protein modifications, and expression changes of the molecules involved have been associated with human diseases. Targeting druggable Ca2+ handling proteins may serve as therapy for neuronal, skeletal muscle, and cardiac or endocrinal diseases. This Issue of IJMS (“Calcium Handling”) presents novel research and reviews in the field of Ca2+ handling proteins’ molecular interplay and regulation in cell physiology and pathophysiology.
Dr. Demetrios A. Arvanitis
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
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- endoplasmic reticulum
- skeletal muscle
- cardiac muscle
- smooth muscle
- pancreatic beta cells