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Special Issue "Calcium Handling"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".

Deadline for manuscript submissions: 30 September 2021.

Special Issue Editor

Dr. Demetrios A. Arvanitis
E-Mail Website
Guest Editor
Center of Basic Research, Biomedical Research Foundation of the Academy of Athens, 115 27 Athens, Greece
Interests: cell biology; physiology; genetics; calcium, cardiomyocytes; neurons

Special Issue Information

Dear Colleagues,

Calcium ion (Ca2+) handling is the central coordinator of excitable cell functions. For neuronal, skeletal, cardiac or smooth muscle, and pancreatic beta cells, transient elevation of intracellular Ca2+ triggers molecular machines and produces key cellular responses, such as contraction and secretion. This is mediated through the maintenance of the resting cytosolic Ca2+ concentration, four orders of magnitude lower than the extracellular space and three orders of magnitude lower than the endoplasmic reticulum or the mitochondria. Upon excitation, these Ca2+ stores release Ca2+ to the cytosol through ion channels, while during relaxation, ATPase pumps reuptake cytosolic Ca2+ to its stores. These channels and pumps are under the control of accessory proteins that modify their function upon extracellular or intracellular signaling. Genetic variations, protein modifications, and expression changes of the molecules involved have been associated with human diseases. Targeting druggable Ca2+ handling proteins may serve as therapy for neuronal, skeletal muscle, and cardiac or endocrinal diseases. This Issue of IJMS (“Calcium Handling”) presents novel research and reviews in the field of Ca2+ handling proteins’ molecular interplay and regulation in cell physiology and pathophysiology.

Dr. Demetrios A. Arvanitis
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Ca2+
  • endoplasmic reticulum
  • mitochondria
  • neurons
  • skeletal muscle
  • cardiac muscle
  • smooth muscle
  • pancreatic beta cells
  • contractility
  • secretion

Published Papers (2 papers)

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Research

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Article
Passive Transfer of Blood Sera from ALS Patients with Identified Mutations Results in Elevated Motoneuronal Calcium Level and Loss of Motor Neurons in the Spinal Cord of Mice
Int. J. Mol. Sci. 2021, 22(18), 9994; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22189994 - 16 Sep 2021
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Abstract
Introduction: Previously, we demonstrated the degeneration of axon terminals in mice after repeated injections of blood sera from amyotrophic lateral sclerosis (ALS) patients with identified mutations. However, whether a similar treatment affects the cell body of motor neurons (MNs) remained unresolved. Methods: Sera [...] Read more.
Introduction: Previously, we demonstrated the degeneration of axon terminals in mice after repeated injections of blood sera from amyotrophic lateral sclerosis (ALS) patients with identified mutations. However, whether a similar treatment affects the cell body of motor neurons (MNs) remained unresolved. Methods: Sera from healthy individuals or ALS patients with a mutation in different ALS-related genes were intraperitoneally injected into ten-week-old male Balb/c mice (n = 3/serum) for two days. Afterward, the perikaryal calcium level was measured using electron microscopy. Furthermore, the optical disector method was used to evaluate the number of lumbar MNs. Results: The cytoplasmic calcium level of the lumbar MNs of the ALS-serum-treated mice, compared to untreated and healthy-serum-treated controls, was significantly elevated. While injections of the healthy serum did not reduce the number of MNs compared to the untreated control group, ALS sera induced a remarkable loss of MNs. Discussion: Similarly to the distant motor axon terminals, the injection of blood sera of ALS patients has a rapid degenerative effect on MNs. Analogously, the magnitude of the evoked changes was specific to the type of mutation; furthermore, the degeneration was most pronounced in the group treated with sera from ALS patients with a mutation in the chromosome 9 open reading frame 72 gene. Full article
(This article belongs to the Special Issue Calcium Handling)
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Review

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Review
Calcium and Heart Failure: How Did We Get Here and Where Are We Going?
Int. J. Mol. Sci. 2021, 22(14), 7392; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22147392 - 09 Jul 2021
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Abstract
The occurrence and prevalence of heart failure remain high in the United States as well as globally. One person dies every 30 s from heart disease. Recognizing the importance of heart failure, clinicians and scientists have sought better therapeutic strategies and even cures [...] Read more.
The occurrence and prevalence of heart failure remain high in the United States as well as globally. One person dies every 30 s from heart disease. Recognizing the importance of heart failure, clinicians and scientists have sought better therapeutic strategies and even cures for end-stage heart failure. This exploration has resulted in many failed clinical trials testing novel classes of pharmaceutical drugs and even gene therapy. As a result, along the way, there have been paradigm shifts toward and away from differing therapeutic approaches. The continued prevalence of death from heart failure, however, clearly demonstrates that the heart is not simply a pump and instead forces us to consider the complexity of simplicity in the pathophysiology of heart failure and reinforces the need to discover new therapeutic approaches. Full article
(This article belongs to the Special Issue Calcium Handling)
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