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Circular RNAs: Biogenesis, Function and Role in Human Disease
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Circular RNAs: Biogenesis, Function and Role in Human Disease

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Genetics and Genomics".

Deadline for manuscript submissions: closed (31 May 2022) | Viewed by 2459

Special Issue Editor

Prof. Dr. Soichiro Yamamura

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Guest Editor
Department of Urology, University of California, San Francisco, CA 94121, USA
Interests: non-coding RNA; cancer; gene expression; cell signaling
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Circular RNA (circRNA) is a single-stranded long non-coding RNA with a covalently closed cyclic structure. Without a 5' end or a 3' poly(A) tail, circRNAs are resistant to exonuclease-mediated degradation and more stable than linear RNAs in cells. 

circRNAs are abundant, highly conserved, tissue-specific, and confined to particular subcellular compartments. circRNAs originate from either exons, introns, or a combination of exons and introns. Exonic circRNAs are mainly located in the cytoplasm; intronic circRNAs are mainly located in nuclei; exon-intronic circRNAs are mainly located in nuclei. 

Accumulated evidence shows that circRNAs possess cellular functions and regulate gene expression and signaling pathways. circRNAs have been shown to be involved in various malignant pathologies such as cancer, Alzheimer's disease, and atherosclerosis. Thus, circRNAs have potential as therapeutic targets and as biomarkers. 

This Special Issue covers recent advances in circRNA studies, such as investigations of functions, biogenesis, and pathologies. We invite contributions in the form of original research articles and reviews. 

Prof. Dr. Soichiro Yamamura
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • circRNA
  • signaling pathways
  • gene expression
  • biogenesis
  • pathology
  • therapy
  • biomarkers

Published Papers (1 paper)

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Review

16 pages, 1152 KiB  
Review
Circular RNAs in Acute Kidney Injury: Roles in Pathophysiology and Implications for Clinical Management
by Benjamin Y. F. So, Desmond Y. H. Yap and Tak Mao Chan
Int. J. Mol. Sci. 2022, 23(15), 8509; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms23158509 - 31 Jul 2022
Cited by 7 | Viewed by 2099
Abstract
Acute kidney injury (AKI) is a common clinical condition, results in patient morbidity and mortality, and incurs considerable health care costs. Sepsis, ischaemia-reperfusion injury (IRI) and drug nephrotoxicity are the leading causes. Mounting evidence suggests that perturbations in circular RNAs (circRNAs) are observed [...] Read more.
Acute kidney injury (AKI) is a common clinical condition, results in patient morbidity and mortality, and incurs considerable health care costs. Sepsis, ischaemia-reperfusion injury (IRI) and drug nephrotoxicity are the leading causes. Mounting evidence suggests that perturbations in circular RNAs (circRNAs) are observed in AKI of various aetiologies, and have pathogenic significance. Aberrant circRNA expressions can cause altered intracellular signalling, exaggerated oxidative stress, increased cellular apoptosis, excess inflammation, and tissue injury in AKI due to sepsis or IRI. While circRNAs are dysregulated in drug-induced AKI, their roles in pathogenesis are less well-characterised. CircRNAs also show potential for clinical application in diagnosis, prognostication, monitoring, and treatment. Prospective observational studies are needed to investigate the role of circRNAs in the clinical management of AKI, with special focus on the safety of therapeutic interventions targeting circRNAs and the avoidance of untoward off-target effects. Full article
(This article belongs to the Special Issue Circular RNAs: Biogenesis, Function and Role in Human Disease)
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