Special Issue "Metabolic Therapies for Heart Failure"
Deadline for manuscript submissions: 31 December 2021.
Heart failure (HF) is a debilitating syndrome associated with the inability of the cardiac pump to deliver enough oxygen and nutrients to the peripheral organs and is accompanied by a high risk of arrhythmia and sudden death. Strongly associated with age, vascular and metabolic comorbidities and sedentary way of life, HF prevalence is fated to rise with the aging of the world population. Currently, even with optimal treatment, mortality rates remain close to 40% at 5 years after prognosis. There is thus an urgent need for new approaches to halt or reverse the course of ventricular dysfunction leading to terminal HF.
This Special Issue focuses on recent developments in the field of metabolic therapies aimed at correcting the metabolic perturbations that characterize the failing heart. These perturbations include inflexibility in the use of energy substrates, severe mitochondrial dysfunction and increased oxidative stress. They all have major consequences not only for cardiac contractility and ion homeostasis but also for cardiac cell survival, intracellular signaling and epigenetic regulation of gene expression. Hence, metabolic therapies can potentially have a broad impact on cardiac physiology, and a combination of many different types of expertise is required to assess their efficacy and safety for the treatment of patients with heart failure.
We warmly welcome the submission of original papers and reviews on new therapeutic strategies addressing these key issues.
Dr. Mathias Mericskay
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Heart failure
- Metabolic therapy
- Nutrition therapy
- Energy metabolism
- Mitochondrial function
- Oxidative stress
- Coenzyme metabolism
- Glucose metabolism
- Fatty acid metabolism
- Ketone body metabolism
- Insulin signaling
- Energy-sensing signaling pathways
- Redox-sensing signaling pathways